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Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks.
Rafii, Hanadi; Bernaudin, Françoise; Rouard, Helene; Vanneaux, Valérie; Ruggeri, Annalisa; Cavazzana, Marina; Gauthereau, Valerie; Stanislas, Aurélie; Benkerrou, Malika; De Montalembert, Mariane; Ferry, Christele; Girot, Robert; Arnaud, Cecile; Kamdem, Annie; Gour, Joelle; Touboul, Claudine; Cras, Audrey; Kuentz, Mathieu; Rieux, Claire; Volt, Fernanda; Cappelli, Barbara; Maio, Karina T; Paviglianiti, Annalisa; Kenzey, Chantal; Larghero, Jerome; Gluckman, Eliane.
Afiliación
  • Rafii H; Eurocord, Paris-Diderot University EA 3518, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, France hanadi.rafii-elayoubi@aphp.fr.
  • Bernaudin F; Monacord, International Observatory for Sickle Cell Disease, Centre Scientifique de Monaco, Monaco.
  • Rouard H; Department of Pediatrics, Referral Center for Sickle Cell Disease, Centre Hospitalier Intercommunal, Paris XII University, Créteil, France.
  • Vanneaux V; Cell Therapy Facility, EFS Ile de France, Créteil, France.
  • Ruggeri A; Cell Therapy Facility, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Cavazzana M; Biotherapy Clinical Investigation Center, Paris-Diderot University, Sorbonne Paris Cité, INSERM, F-75010, France.
  • Gauthereau V; Eurocord, Paris-Diderot University EA 3518, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Stanislas A; Monacord, International Observatory for Sickle Cell Disease, Centre Scientifique de Monaco, Monaco.
  • Benkerrou M; Biotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • De Montalembert M; Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, Assistance Publique-Hôpitaux de Paris, INSERM, France.
  • Ferry C; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, France.
  • Girot R; Fédération Parisienne Pour le Dépistage et la Prévention des Handicaps de l'Enfant (FPDPHE), Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Arnaud C; Biotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Kamdem A; Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, Assistance Publique-Hôpitaux de Paris, INSERM, France.
  • Gour J; Department of Pediatrics, Referral Center for Sickle Cell Disease, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Touboul C; Department of Pediatrics, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Cras A; Department of Stem Cell Transplantation, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Kuentz M; Department of Hemato-Biology, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Rieux C; Department of Pediatrics, Referral Center for Sickle Cell Disease, Centre Hospitalier Intercommunal, Paris XII University, Créteil, France.
  • Volt F; Department of Pediatrics, Referral Center for Sickle Cell Disease, Centre Hospitalier Intercommunal, Paris XII University, Créteil, France.
  • Cappelli B; Department of Gynecology, Centre Hospitalier Intercommunal, Créteil, France.
  • Maio KT; Department of Gynecology, Centre Hospitalier Intercommunal, Créteil, France.
  • Paviglianiti A; Cell Therapy Facility, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, France.
  • Kenzey C; Biotherapy Clinical Investigation Center, Paris-Diderot University, Sorbonne Paris Cité, INSERM, F-75010, France.
  • Larghero J; Department of Hematology, Groupe Hospitalier Universitaire Henri-Mondor, Créteil, France.
  • Gluckman E; Unité d'Hémovigilance, Groupe Hospitalier Universitaire Henri-Mondor, Créteil, France.
Haematologica ; 102(6): 976-983, 2017 06.
Article en En | MEDLINE | ID: mdl-28302713
Efforts to implement family cord blood banking have been developed in the past decades for siblings requiring stem cell transplantation for conditions such as sickle cell disease. However, public banks are faced with challenging decisions about the units to be stored, discarded, or used for other endeavors. We report here 20 years of experience in family cord blood banking for sickle cell disease in two dedicated public banks. Participants were pregnant women who had a previous child diagnosed with homozygous sickle cell disease. Participation was voluntary and free of charge. All mothers underwent mandatory serological screening. Cord blood units were collected in different hospitals, but processed and stored in two public banks. A total of 338 units were stored for 302 families. Median recipient age was six years (11 months-15 years). Median collected volume and total nucleated cell count were 91 mL (range 23-230) and 8.6×108 (range 0.7-75×108), respectively. Microbial contamination was observed in 3.5% (n=12), positive hepatitis B serology in 25% (n=84), and homozygous sickle cell disease in 11% (n=37) of the collections. Forty-four units were HLA-identical to the intended recipient, and 28 units were released for transplantation either alone (n=23) or in combination with the bone marrow from the same donor (n=5), reflecting a utilization rate of 8%. Engraftment rate was 96% with 100% survival. Family cord blood banking yields good quality units for sibling transplantation. More comprehensive banking based on close collaboration among banks, clinical and transplant teams is recommended to optimize the use of these units.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Familia / Trasplante de Células Madre de Sangre del Cordón Umbilical / Sangre Fetal / Almacenamiento de Sangre / Anemia de Células Falciformes Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Pregnancy Idioma: En Revista: Haematologica Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Familia / Trasplante de Células Madre de Sangre del Cordón Umbilical / Sangre Fetal / Almacenamiento de Sangre / Anemia de Células Falciformes Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Pregnancy Idioma: En Revista: Haematologica Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Italia