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Circulating progenitor cells in hypertensive subjects: Effectiveness of a treatment with olmesartan in improving cell number and miR profile in addition to expected pharmacological effects.
Mandraffino, Giuseppe; Aragona, Caterina Oriana; Cairo, Valentina; Scuruchi, Michele; Lo Gullo, Alberto; D'Ascola, Angela; Alibrandi, Angela; Loddo, Saverio; Quartuccio, Sebastiano; Morace, Carmela; Mormina, Enricomaria; Basile, Giorgio; Saitta, Antonino; Imbalzano, Egidio.
Afiliación
  • Mandraffino G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Aragona CO; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Cairo V; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Scuruchi M; Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy.
  • Lo Gullo A; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • D'Ascola A; Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy.
  • Alibrandi A; Department of Statistics, University of Messina, Messina, Italy.
  • Loddo S; Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy.
  • Quartuccio S; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Morace C; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Mormina E; Department of Biomedical Sciences and of Morphologic and Functional Images, University of Messina, Messina, Italy.
  • Basile G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Saitta A; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Imbalzano E; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
PLoS One ; 12(3): e0173030, 2017.
Article en En | MEDLINE | ID: mdl-28301500
CD34+ circulating progenitor cells (CD34+CPCs) are a population of multipotent cells which can delay the development of atherosclerosis and cardiovascular disease (CVD) in conditions of increased CV risk. MicroRNAs (miRs) 221 and 222 modulate different genes regulating angiogenesis and inflammation; moreover, miR221/22 have beenshown to participate in differentiation and proliferation of CD34+CPCs, inhibiting cell migration and homing. miR221/222 in CD34+CPCs from hypertensive subjects are also increased and associated with CD34+cell number and reactive oxygen species (ROS). We evaluated CD34+CPC number, intracellular miR221/222 and ROS levels, arterial stiffness (AS)and echocardiography indices at baseline (T0).Then, after a six-month treatment with olmesartan, 20 mg/day (T1), in 57 hypertensive patients with left ventricular hypertrophy (LVH) and with no additional risk factor for CVD, and in 29 healthy controls (baseline),fibrinogen, C-reactive protein (CRP), glucose and lipid profiles were also evaluated.At T1, blood pressure values, CRP and fibrinogen levels, ROS and miR221/222 were significantly decreased (all p <0.001), as were AS indices and LV mass index (p<0.001), while cell number was increased (p<0.001). Olmesartan is effective in reducing miR and ROS levels in CD34+CPCs from hypertensive subjects, as well as in increasing CD34+CPC number, providing multilevel CV protection, in addition to its expected pharmacological effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Tetrazoles / MicroARNs / Hipertensión / Imidazoles / Antihipertensivos Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Tetrazoles / MicroARNs / Hipertensión / Imidazoles / Antihipertensivos Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos