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Protective Effects of Fucoidan on Aß25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice.
Wei, Hengyun; Gao, Zixiang; Zheng, Luping; Zhang, Cuili; Liu, Zundong; Yang, Yazong; Teng, Hongming; Hou, Lin; Yin, Yuling; Zou, Xiangyang.
Afiliación
  • Wei H; Department of Biotechnology, Dalian Medical University, Dalian 116044, China. weihengyun@126.com.
  • Gao Z; Department of Biotechnology, Dalian Medical University, Dalian 116044, China. 18641548759@163.com.
  • Zheng L; College of Integrative Medicine, Dalian Medical University, Dalian 116044, China. zzllpp311@163.com.
  • Zhang C; Department of Biotechnology, Dalian Medical University, Dalian 116044, China. biot_zhangcl@sina.com.
  • Liu Z; Department of Biotechnology, Dalian Medical University, Dalian 116044, China. harryblood1989@126.com.
  • Yang Y; Department of Biotechnology, Dalian Medical University, Dalian 116044, China. yangyazong123@126.com.
  • Teng H; Department of Biotechnology, Dalian Medical University, Dalian 116044, China. thm0529@126.com.
  • Hou L; College of Life Sciences, Liaoning Normal University, Dalian 116081, China. houlin01@126.com.
  • Yin Y; Department of Biotechnology, Dalian Medical University, Dalian 116044, China. yinyulingdl@dlmedu.edu.cn.
  • Zou X; Department of Biotechnology, Dalian Medical University, Dalian 116044, China. zouxiangyang@126.com.
Mar Drugs ; 15(3)2017 Mar 16.
Article en En | MEDLINE | ID: mdl-28300775
Alzheimer's disease (AD) is a chronic neurodegenerative disease which contributes to memory loss and cognitive decline in the elderly. Fucoidan, extracted from brown algae, is a complex sulfated polysaccharide and potential bioactive compound. In this study, we investigated whether fucoidan protects PC12 cells from apoptosis induced by a combination of beta-amyloid 25-35 (Aß25-35) and d-galactose (d-Gal), and improves learning and memory impairment in AD model mice. The results indicated that fucoidan could inhibit the release of cytochrome c from the mitochondria to cytosol and activation of caspases, and increase the expression of apoptosis inhibitor proteins (IAPs), including livin and X-linked IAP (XIAP) in PC12 cells damaged by Aß25-35 and d-Gal-induction. Fucoidan reversed the decreased activity of acetylcholine (ACh) and choline acetyl transferase (ChAT), as well as the increased activity of acetylcholine esterase (AChE), in AD model mice induced by infusion of d-Gal. Furthermore, fucoidan improved antioxidant activity in vitro and in vivo by activation of superoxide dismutase (SOD) and glutathione (GSH). These results suggested that fucoidan could protect PC12 cells from apoptosis and ameliorate the learning and memory impairment in AD model mice, which appeared to be due to regulating the cholinergic system, reducing oxidative stress, and inhibiting the caspase-dependent apoptosis pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Polisacáridos / Péptidos beta-Amiloides / Fármacos Neuroprotectores / Síndromes de Neurotoxicidad / Disfunción Cognitiva / Galactosa Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Polisacáridos / Péptidos beta-Amiloides / Fármacos Neuroprotectores / Síndromes de Neurotoxicidad / Disfunción Cognitiva / Galactosa Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza