[Immunological mechanisms of allergen-specific immunotherapy]. / Immunologische Mechanismen der allergenspezifischen Immuntherapie.
Hautarzt
; 68(4): 265-270, 2017 Apr.
Article
en De
| MEDLINE
| ID: mdl-28299382
Allergen-specific immunotherapy is accompanied by multiple changes on the cellular and humoral level. A shift of Th2 immune responses towards immune responses of the Th1 type, which goes along with an increase of regulatory T cells and B cells, IL-10 as well as reduction of effector cells and eosinophils in the tissue, combined with lower IgE production in favor of higher IgG4 production, are regarded as key mechanisms of allergen-specific immunotherapy . A better understanding of immunologic pathways of specific immunotherapy would be essential for the improvement of this therapy as well as for the development of reliable biomarkers capable to monitor therapeutic responses as well as compliance of the patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alérgenos
/
Desensibilización Inmunológica
/
Modelos Inmunológicos
/
Hipersensibilidad
/
Leucocitos
Límite:
Animals
/
Humans
Idioma:
De
Revista:
Hautarzt
Año:
2017
Tipo del documento:
Article
Pais de publicación:
Alemania