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The extracellular domain of E cadherin linked to invasiveness in colorectal cancer: a new resistance and relapses monitoring serum-bio marker?
Christou, Niki; Perraud, Aurélie; Blondy, Sabrina; Jauberteau, Marie-Odile; Battu, Serge; Mathonnet, Muriel.
Afiliación
  • Christou N; Laboratoire EA 3842, Homéostasie cellulaire et Pathologies, Faculté de Médecine et de Pharmacie, Université de Limoges, 2 rue du Dr Marcland, 87025, Limoges Cedex, France. christou.niki19@gmail.com.
  • Perraud A; Institut Fédératif de Recherche 145 GEIST « Génomique, Environnement, Immunité, Santé et Thérapeutiques ¼, Université de Limoges, 2 rue du Dr Marcland, 87025, Limoges Cedex, France. christou.niki19@gmail.com.
  • Blondy S; Service de chirurgie digestive générale et endocrinienne, CHRU de Limoges, 2 rue Martin Luther King, 87042, Limoges Cedex, France. christou.niki19@gmail.com.
  • Jauberteau MO; Laboratoire EA 3842, Homéostasie cellulaire et Pathologies, Faculté de Médecine et de Pharmacie, Université de Limoges, 2 rue du Dr Marcland, 87025, Limoges Cedex, France.
  • Battu S; Institut Fédératif de Recherche 145 GEIST « Génomique, Environnement, Immunité, Santé et Thérapeutiques ¼, Université de Limoges, 2 rue du Dr Marcland, 87025, Limoges Cedex, France.
  • Mathonnet M; Service de chirurgie digestive générale et endocrinienne, CHRU de Limoges, 2 rue Martin Luther King, 87042, Limoges Cedex, France.
J Cancer Res Clin Oncol ; 143(7): 1177-1190, 2017 Jul.
Article en En | MEDLINE | ID: mdl-28289897
PURPOSE: Multiple studies have attempted to demonstrate the interest of the cell adhesion marker, E cadherin, as a diagnostic and prognosis marker in colorectal cancer (CRC). However, it was considered non specific. MATERIALS AND METHODS: Studies were carried out with CRC cell lines and patients' cohort operated for CRC. The expression of E cadherin was studied after 5 fluorouracil (5FU) treatment and correlated to CRC relapse, chemo-resistance and survival. RESULTS: In CRC cell lines derived from high tumor stages, extracellular domain of E cadherin expression decreased after 5FU treatment whereas it increased in supernatants. Interestingly, only specific cleaved forms at 55 kDa of E cadherin were detected in supernatants. In CRC surgical patients, more importantly concerning extracellular E cadherin domain, a decreased expression was observed in tissues in function of CRC stages whereas an increased expression was found in sera. Moreover, there is an increasing trend of survival with weak serum E cadherin secretion, reinforcing the implication of this protein in CRC evolution. DISCUSSION: The extracellular domain can be defined as a 5FU resistance marker and allow CRC monitoring.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Biomarcadores de Tumor / Cadherinas / Invasividad Neoplásica Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cancer Res Clin Oncol Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Biomarcadores de Tumor / Cadherinas / Invasividad Neoplásica Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cancer Res Clin Oncol Año: 2017 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania