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Structural insights into the EthR-DNA interaction using native mass spectrometry.
Shiu-Hin Chan, Daniel; Seetoh, Wei-Guang; McConnell, Brendan N; Matak-Vinkovic, Dijana; Thomas, Sherine E; Mendes, Vitor; Blaszczyk, Michal; Coyne, Anthony G; Blundell, Tom L; Abell, Chris.
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  • Shiu-Hin Chan D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
  • Seetoh WG; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
  • McConnell BN; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
  • Matak-Vinkovic D; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
  • Thomas SE; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
  • Mendes V; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
  • Blaszczyk M; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
  • Coyne AG; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
  • Blundell TL; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
  • Abell C; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK. ca26@cam.ac.uk.
Chem Commun (Camb) ; 53(25): 3527-3530, 2017 Mar 23.
Article en En | MEDLINE | ID: mdl-28287239
EthR is a transcriptional repressor that increases Mycobacterium tuberculosis resistance to ethionamide. In this study, the EthR-DNA interaction has been investigated by native electrospray-ionization mass spectrometry for the first time. The results show that up to six subunits of EthR are able to bind to its operator.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Bacteriano / Etionamida Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Bacteriano / Etionamida Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido