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Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States.
Giudici, Kelly Virecoulon; Kindler, Joseph M; Martin, Berdine R; Laing, Emma M; McCabe, George P; McCabe, Linda D; Hausman, Dorothy B; Martini, Lígia Araújo; Lewis, Richard D; Weaver, Connie M; Peacock, Munro; Hill Gallant, Kathleen M.
Afiliación
  • Giudici KV; Department of Nutrition, School of Public Health, University of São Paulo, Avenida Doutor Arnaldo 715, São Paulo, CEP 01246-904 Brazil.
  • Kindler JM; Department of Foods and Nutrition, University of Georgia, 305 Sanford Dr, Athens, GA 30602 USA.
  • Martin BR; Department of Nutrition Science, Purdue University, 700 W. State Street, West Lafayette, IN 47907 USA.
  • Laing EM; Department of Foods and Nutrition, University of Georgia, 305 Sanford Dr, Athens, GA 30602 USA.
  • McCabe GP; Department of Statistics, Purdue University, 150 N. University Street, West Lafayette, IN 47907 USA.
  • McCabe LD; Department of Nutrition Science, Purdue University, 700 W. State Street, West Lafayette, IN 47907 USA.
  • Hausman DB; Department of Foods and Nutrition, University of Georgia, 305 Sanford Dr, Athens, GA 30602 USA.
  • Martini LA; Department of Nutrition, School of Public Health, University of São Paulo, Avenida Doutor Arnaldo 715, São Paulo, CEP 01246-904 Brazil.
  • Lewis RD; Department of Foods and Nutrition, University of Georgia, 305 Sanford Dr, Athens, GA 30602 USA.
  • Weaver CM; Department of Nutrition Science, Purdue University, 700 W. State Street, West Lafayette, IN 47907 USA.
  • Peacock M; Department of Medicine, Indiana University School of Medicine, 545 Barnhill Dr, Indianapolis, IN 46202 USA.
  • Hill Gallant KM; Department of Nutrition Science, Purdue University, 700 W. State Street, West Lafayette, IN 47907 USA.
Nutr Metab (Lond) ; 14: 25, 2017.
Article en En | MEDLINE | ID: mdl-28286536
BACKGROUND: This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9-13 years. METHODS: This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9-13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed. RESULTS: Approximately 52% of study participants were obese based on percent body fat cutoffs (>25% for boys and >32% for girls) and about 5% had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL). Serum tOC was not correlated with leptin, glucose, insulin, HOMA-IR, or HOMA-ß after adjusting for percent body fat. However, serum ucOC negatively correlated with leptin (partial r = -0.16; p = 0.04) and glucose (partial r = -0.16; p = 0.04) after adjustment for percent body fat. Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-ß after adjusting for age, sex and percent body fat (all p < 0.001). CONCLUSIONS: These data depict an inverse relationship between leptin and various metabolic health outcomes in children. However, the notion that tOC or ucOC link fat with energy metabolism in healthy children was not supported. CLINICAL TRIAL REGISTRATION NUMBER: NCT00931580.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nutr Metab (Lond) Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nutr Metab (Lond) Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido