Your browser doesn't support javascript.
loading
Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression.
Singh, Ruma G; Yoon, Harry D; Wu, Landy M; Lu, Jun; Plank, Lindsay D; Petrov, Maxim S.
Afiliación
  • Singh RG; Department of Surgery, University of Auckland, Auckland, New Zealand.
  • Yoon HD; Department of Surgery, University of Auckland, Auckland, New Zealand.
  • Wu LM; Department of Surgery, University of Auckland, Auckland, New Zealand.
  • Lu J; Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.
  • Plank LD; Department of Surgery, University of Auckland, Auckland, New Zealand.
  • Petrov MS; Department of Surgery, University of Auckland, Auckland, New Zealand. Electronic address: max.petrov@gmail.com.
Metabolism ; 69: 1-13, 2017 Apr.
Article en En | MEDLINE | ID: mdl-28285638
OBJECTIVE: Growing evidence suggests that individuals with excessive fat in the pancreas are at an increased risk of chronic metabolic disorders. The aim was to systematically review studies on non-alcoholic fatty pancreas disease (NAFPD) with a view to determine its prevalence, associations with metabolic co-morbidities, and to suggest normal pancreatic fat percentage threshold. METHODS: Three electronic databases (MEDLINE, Scopus, and Embase) were queried. Studies in humans were eligible for inclusion if they provided data on NAFPD and/or pancreatic fat percentage. Where possible, data were pooled using random-effects meta-analysis and the effect of covariates analysed using meta-regression. RESULTS: Pooling data on pancreatic fat percentage from nine studies (1209 healthy individuals who underwent magnetic resonance imaging), yielded the weighted mean and weighted standard deviation of 4.48% and 0.87%, respectively. Pooling data on NAFPD from eleven studies (12,675 individuals), yielded the pooled prevalence of 33% (95% confidence interval, 24% - 41%). Meta-regression analysis showed that the prevalence of NAFPD was independent of age and sex. The presence of NAFPD was associated with a significantly increased risk of arterial hypertension (risk ratio 1.67; 95% confidence interval, 1.32-2.10; p<0.0001), diabetes mellitus (risk ratio 2.08; 95% confidence interval, 1.44-3.00; p=0.0001), and metabolic syndrome (risk ratio 2.37; 95% confidence interval, 2.07-2.71; p<0.0001). CONCLUSION: The findings indicate that NAFPD is a frequent clinical entity, associated with significantly increased risk of metabolic syndrome and its components. The normal pancreatic fat cut-off point of 6.2% may be recommended for use in future prospective studies.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Enfermedades Pancreáticas / Metabolismo de los Lípidos / Grasas Tipo de estudio: Observational_studies / Prevalence_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Metabolism Año: 2017 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Enfermedades Pancreáticas / Metabolismo de los Lípidos / Grasas Tipo de estudio: Observational_studies / Prevalence_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Metabolism Año: 2017 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Estados Unidos