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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Xu, Jiayi; Lin, Songnian; Myers, Robert W; Addona, George; Berger, Joel P; Campbell, Brian; Chen, Hsuan-Shen; Chen, Zhesheng; Eiermann, George J; Elowe, Nadine H; Farrer, Brian T; Feng, Wen; Fu, Qinghong; Kats-Kagan, Roman; Kavana, Michael; Malkani, Sunita; McMasters, Daniel R; Mitra, Kaushik; Pachanski, Michele J; Tong, Xinchun; Trujillo, Maria E; Xu, Libo; Zhang, Bei; Zhang, Fengqi; Zhang, Rui; Parmee, Emma R.
Afiliación
  • Xu J; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA. Electronic address: Jiayi_xu@merck.com.
  • Lin S; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA. Electronic address: songnian_lin@merck.com.
  • Myers RW; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Addona G; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Berger JP; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Campbell B; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Chen HS; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Chen Z; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Eiermann GJ; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Elowe NH; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Farrer BT; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Feng W; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Fu Q; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Kats-Kagan R; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Kavana M; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Malkani S; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • McMasters DR; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Mitra K; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Pachanski MJ; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Tong X; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Trujillo ME; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Xu L; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Zhang B; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Zhang F; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Zhang R; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
  • Parmee ER; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ, USA.
Bioorg Med Chem Lett ; 27(9): 2069-2073, 2017 05 01.
Article en En | MEDLINE | ID: mdl-28284804
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activadores de Enzimas / Diabetes Mellitus Tipo 2 / Glucoquinasa / Hipoglucemiantes / Indoles Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activadores de Enzimas / Diabetes Mellitus Tipo 2 / Glucoquinasa / Hipoglucemiantes / Indoles Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido