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Long Non-Coding RNA as Potential Biomarker for Prostate Cancer: Is It Making a Difference?
Deng, Junli; Tang, Jie; Wang, Guo; Zhu, Yuan-Shan.
Afiliación
  • Deng J; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. 147311014@csu.edu.cn.
  • Tang J; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China. 147311014@csu.edu.cn.
  • Wang G; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China. jietang@csu.edu.cn.
  • Zhu YS; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China. jietang@csu.edu.cn.
Int J Environ Res Public Health ; 14(3)2017 03 07.
Article en En | MEDLINE | ID: mdl-28272371
Whole genome transcriptomic analyses have identified numerous long non-coding RNA (lncRNA) transcripts that are increasingly implicated in cancer biology. LncRNAs are found to promote essential cancer cell functions such as proliferation, invasion, and metastasis, with the potential to serve as novel biomarkers of various cancers and to further reveal uncharacterized aspects of tumor biology. However, the biological and molecular mechanisms as well as the clinical applications of lncRNAs in diverse diseases are not completely understood, and remain to be fully explored. LncRNAs may be critical players and regulators in prostate cancer carcinogenesis and progression, and could serve as potential biomarkers for prostate cancer. This review focuses on lncRNA biomarkers that are already available for clinical use and provides an overview of lncRNA biomarkers that are under investigation for clinical development in prostate cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / ARN Largo no Codificante Límite: Humans / Male Idioma: En Revista: Int J Environ Res Public Health Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / ARN Largo no Codificante Límite: Humans / Male Idioma: En Revista: Int J Environ Res Public Health Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza