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Acupuncture reduces relapse to cocaine-seeking behavior via activation of GABA neurons in the ventral tegmental area.
Jin, Wyju; Kim, Min Sun; Jang, Eun Young; Lee, Jun Yeon; Lee, Jin Gyeom; Kim, Hong Yu; Yoon, Seong Shoon; Lee, Bong Hyo; Chang, Suchan; Kim, Jae Hyo; Choi, Kwang H; Koo, Ho; Gwak, Young Seob; Steffensen, Scott C; Ryu, Yeon-Hee; Kim, Hee Young; Yang, Chae Ha.
Afiliación
  • Jin W; College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Kim MS; Department of Physiology, School of Medicine, Wonkwang University, Iksan, South Korea.
  • Jang EY; College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Lee JY; Convergence Research Center, College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Lee JG; College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Kim HY; College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Yoon SS; College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Lee BH; Research Center of Safety Pharmacology, Korea Institute of Toxicity, Daejeon, South Korea.
  • Chang S; College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Kim JH; College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Choi KH; Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University, Iksan, South Korea.
  • Koo H; Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
  • Gwak YS; Department of Physiology, School of Medicine, Wonkwang University, Iksan, South Korea.
  • Steffensen SC; College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Ryu YH; Convergence Research Center, College of Korean Medicine, Daegu Haany University, Daegu, South Korea.
  • Kim HY; Department of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT, USA.
  • Yang CH; Acupuncture, Moxibustion & Meridian Research Center, Division of Standard Research, Korea Institute of Oriental Medicine, Daejeon, South Korea.
Addict Biol ; 23(1): 165-181, 2018 01.
Article en En | MEDLINE | ID: mdl-28271626
There is growing public interest in alternative approaches to addiction treatment and scientific interest in elucidating the neurobiological underpinnings of acupuncture. Our previous studies showed that acupuncture at a specific Shenmen (HT7) points reduced dopamine (DA) release in the nucleus accumbens (NAc) induced by drugs of abuse. The present study was carried out to evaluate the effects of HT7 acupuncture on γ-aminobutyric acid (GABA) neuronal activity in the ventral tegmental area (VTA) and the reinstatement of cocaine-seeking behavior. Using microdialysis and in vivo single-unit electrophysiology, we evaluated the effects of HT7 acupuncture on VTA GABA and NAc DA release and VTA GABA neuronal activity in rats. Using a within-session reinstatement paradigm in rats self-administering cocaine, we evaluated the effects of HT7 stimulation on cocaine-primed reinstatement. Acupuncture at HT7 significantly reduced cocaine suppression of GABA release and GABA neuron firing rates in the VTA. HT7 acupuncture attenuated cocaine-primed reinstatement, which was blocked by VTA infusions of the selective GABAB receptor antagonist 2-hydroxysaclofen. HT7 stimulation significantly decreased acute cocaine-induced DA release in the NAc, which was also blocked by 2-hydroxysaclofen. HT7 acupuncture also attenuated cocaine-induced sensitization of extracellular DA levels in the NAc. Moreover, HT7 acupuncture reduced both locomotor activity and neuronal activation in the NAc induced by acute cocaine in a needle-penetration depth-dependent fashion. These results suggest that acupuncture may suppress cocaine-induced DA release in the NAc and cocaine-seeking behavior through activation of VTA GABA neurons. Acupuncture may be an effective therapy to reduce cocaine relapse by enhancing GABAergic inhibition in the VTA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Cocaína / Área Tegmental Ventral / Inhibidores de Captación de Dopamina / Acupuntura / Comportamiento de Búsqueda de Drogas / Locomoción Límite: Animals Idioma: En Revista: Addict Biol Asunto de la revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Año: 2018 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos
Texto completo
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Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Cocaína / Área Tegmental Ventral / Inhibidores de Captación de Dopamina / Acupuntura / Comportamiento de Búsqueda de Drogas / Locomoción Límite: Animals Idioma: En Revista: Addict Biol Asunto de la revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Año: 2018 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos