Reduced expression of MHC class I antigens in chicken fibroblasts transformed by Rous sarcoma virus.
Folia Biol (Praha)
; 33(5): 325-34, 1987.
Article
en En
| MEDLINE
| ID: mdl-2826262
Monoclonal monomorphic as well as polyclonal antibodies against H-B class I (B-F) antigen were used to evaluate the expression of these molecules on normal and RSV-transformed chick embryo fibroblasts. The results indicate that chicken fibroblasts transformed in vitro by the Schmidt-Ruppin strain Rous sarcoma virus of subgroup B (SR-RSV-B) present reduced H-B class I antigen expression as compared to uninfected cells of the same inbred strain. This quantitative reduction was observed at the cell membrane and in whole cell lysates. Chick embryo fibroblasts infected with avian leukosis virus RAV-1 show that the levels of H-B class I antigens were indistinguishable from the levels measured on the control cells. Normal embryo fibroblasts derived from the inbred lines B4/B4 express higher levels of H-B antigens than normal cells carrying the B12/B12 genotype.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transformación Celular Neoplásica
/
Virus del Sarcoma Aviar
/
Antígenos HLA
/
Complejo Mayor de Histocompatibilidad
Límite:
Animals
Idioma:
En
Revista:
Folia Biol (Praha)
Año:
1987
Tipo del documento:
Article
Pais de publicación:
República Checa