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Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniae and Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil.
Rocha, Larissa C; Carvalho, Magda O S; Nascimento, Valma M L; Dos Santos, Milena S; Barros, Tânia F; Adorno, Elisângela V; Reis, Joice N; da Guarda, Caroline C; Santiago, Rayra P; Gonçalves, Marilda de Souza.
Afiliación
  • Rocha LC; Fundação de Hematologia e Hemoterapia da Bahia Bahia, Brazil.
  • Carvalho MO; Centro de Pesquisa Gonçalo Moniz-FiocruzBahia, Brazil; Faculdade de Farmácia, Universidade Federal da BahiaBahia, Brazil; Hospital Universitário Professor Edgard Santos - Universidade Federal da Bahia (HUPES-UFBA)Bahia, Brazil.
  • Nascimento VM; Fundação de Hematologia e Hemoterapia da Bahia Bahia, Brazil.
  • Dos Santos MS; Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia Bahia, Brazil.
  • Barros TF; Faculdade de Farmácia, Universidade Federal da Bahia Bahia, Brazil.
  • Adorno EV; Faculdade de Farmácia, Universidade Federal da Bahia Bahia, Brazil.
  • Reis JN; Faculdade de Farmácia, Universidade Federal da Bahia Bahia, Brazil.
  • da Guarda CC; Centro de Pesquisa Gonçalo Moniz-Fiocruz Bahia, Brazil.
  • Santiago RP; Centro de Pesquisa Gonçalo Moniz-Fiocruz Bahia, Brazil.
  • Gonçalves MS; Centro de Pesquisa Gonçalo Moniz-FiocruzBahia, Brazil; Faculdade de Farmácia, Universidade Federal da BahiaBahia, Brazil.
Front Microbiol ; 8: 217, 2017.
Article en En | MEDLINE | ID: mdl-28261176
We investigated the nasopharynx and oropharynx microbiota in sickle cell disease (SCD) to identify the microorganisms, antibiotic sensitivity, prevalent serotypes, and association of with laboratorial markers. Oropharynx/nasopharynx secretions were investigated in 143 SCD children aging 6 months to 17 years. Pathogens were isolated using standard procedures, and laboratorial markers were performed by automated methods. Staphylococcus aureus (S. aureus) was isolated from nasopharynx and oropharynx of 64 and of 17 SCD children respectively. Streptococcus pneumoniae (S. pneumoniae) was isolated from the nasopharynx and oropharynx of eight SCD patients. Serotypes of S. pneumoniae were 19F, 23F, and 14. All isolates were susceptible to penicillin, and patients whose nasopharynx and oropharynx were colonized by S. pneumoniae had high concentrations of aspartate transaminase, alanine transaminase, and ferritin. S. pneumoniae isolated were not penicillin-resistant serotypes suggesting that the use of penicillin for prophylaxis and/or treatment of infections is safe. Our finding of colonization and laboratory evaluation in SCD patients suggests that microorganisms are involved in the modulation of chronic inflammatory. The association of colonized microorganisms and laboratorial markers suggest a new approach to these patients follow-up, and additional studies of microorganism colonization and their association with SCD patients' clinical outcome will improve control and prevention strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Front Microbiol Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies País/Región como asunto: America do sul / Brasil Idioma: En Revista: Front Microbiol Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza