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The effect of paternal methyl-group donor intake on offspring DNA methylation and birth weight.
Pauwels, S; Truijen, I; Ghosh, M; Duca, R C; Langie, S A S; Bekaert, B; Freson, K; Huybrechts, I; Koppen, G; Devlieger, R; Godderis, L.
Afiliación
  • Pauwels S; 1Department of Public Health and Primary Care, Environment and Health,KU Leuven- University of Leuven,Leuven,Belgium.
  • Truijen I; 1Department of Public Health and Primary Care, Environment and Health,KU Leuven- University of Leuven,Leuven,Belgium.
  • Ghosh M; 1Department of Public Health and Primary Care, Environment and Health,KU Leuven- University of Leuven,Leuven,Belgium.
  • Duca RC; 1Department of Public Health and Primary Care, Environment and Health,KU Leuven- University of Leuven,Leuven,Belgium.
  • Langie SAS; 2Unit Environmental Risk and Health,Flemish Institute of Technological Research (VITO),Mol,Belgium.
  • Bekaert B; 4Department of Imaging & Pathology,KU Leuven - University of Leuven,Leuven,Belgium.
  • Freson K; 6Center for Molecular and Vascular Biology,KU Leuven - University of Leuven,Leuven,Belgium.
  • Huybrechts I; 7Dietary Exposure Assessment Group,International Agency for Research on Cancer,Lyon,France.
  • Koppen G; 2Unit Environmental Risk and Health,Flemish Institute of Technological Research (VITO),Mol,Belgium.
  • Devlieger R; 8Department of Development and Regeneration,KU Leuven-University of Leuven,Leuven,Belgium.
  • Godderis L; 1Department of Public Health and Primary Care, Environment and Health,KU Leuven- University of Leuven,Leuven,Belgium.
J Dev Orig Health Dis ; 8(3): 311-321, 2017 Jun.
Article en En | MEDLINE | ID: mdl-28260562
Most nutritional studies on the development of children focus on mother-infant interactions. Maternal nutrition is critically involved in the growth and development of the fetus, but what about the father? The aim is to investigate the effects of paternal methyl-group donor intake (methionine, folate, betaine, choline) on paternal and offspring global DNA (hydroxy)methylation, offspring IGF2 DMR DNA methylation, and birth weight. Questionnaires, 7-day estimated dietary records, whole blood samples, and anthropometric measurements from 74 fathers were obtained. A total of 51 cord blood samples were collected and birth weight was obtained. DNA methylation status was measured using liquid chromatography-tandem mass spectrometry (global DNA (hydroxy)methylation) and pyrosequencing (IGF2 DMR methylation). Paternal betaine intake was positively associated with paternal global DNA hydroxymethylation (0.028% per 100 mg betaine increase, 95% CI: 0.003, 0.053, P=0.03) and cord blood global DNA methylation (0.679% per 100 mg betaine increase, 95% CI: 0.057, 1.302, P=0.03). Paternal methionine intake was positively associated with CpG1 (0.336% per 100 mg methionine increase, 95% CI: 0.103, 0.569, P=0.006), and mean CpG (0.201% per 100 mg methionine increase, 95% CI: 0.001, 0.402, P=0.049) methylation of the IGF2 DMR in cord blood. Further, a negative association between birth weight/birth weight-for-gestational age z-score and paternal betaine/methionine intake was found. In addition, a positive association between choline and birth weight/birth weight-for-gestational age z-score was also observed. Our data indicate a potential impact of paternal methyl-group donor intake on paternal global DNA hydroxymethylation, offspring global and IGF2 DMR DNA methylation, and prenatal growth.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Betaína / Peso al Nacer / Colina / Metilación de ADN / Ácido Fólico / Metionina Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Dev Orig Health Dis Año: 2017 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Betaína / Peso al Nacer / Colina / Metilación de ADN / Ácido Fólico / Metionina Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Dev Orig Health Dis Año: 2017 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido