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Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT­Hc in mice.
Yang, Yilong; Yu, Rui; Yang, Xiuxu; Liu, Shuling; Fang, Ting; Song, Xiaohong; Hou, Lihua; Yu, Changming; Xu, Junjie; Fu, Ling; Yi, Shaoqiong; Chen, Wei.
Afiliación
  • Yang Y; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Yu R; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Yang X; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Liu S; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Fang T; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Song X; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Hou L; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Yu C; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Xu J; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Fu L; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Yi S; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
  • Chen W; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China.
Mol Med Rep ; 15(4): 2369-2373, 2017 Apr.
Article en En | MEDLINE | ID: mdl-28259925
In developing countries, trauma patients and neonates are vulnerable to Staphylococcus aureus (S. aureus) and Clostridium tetani infections. It has been suggested that a combined vaccine against the two infections may be a reliable and cost­effective strategy. Previous studies have indicated that the S. aureus surface protein A (SasA) and the C fragment of tetanus neurotoxin (TeNT­Hc) may be suitable candidates for a vaccine against S. aureus and tetanus infections, respectively. In the present study, mice were immunized with a combined vaccine containing SasA and TeNT­Hc, which induced a robust immune response to both antigens, and mutual interference between SasA and TeNT­Hc was not observed. In the S.aureus challenge model, the combined vaccine fully protected BALB/c mice against lethal intraperitoneal challenges with 3x109 colony­forming units of a methicillin­resistant S. aureus USA300 strain. In the TeNT challenge model, the combined vaccine conferred complete protection against a lethal dose of (2x103) xLD50 tetanus toxin. These results implied that SasA and TeNT­Hc promising components for a combined vaccine against S. aureus and tetanus infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus / Tétanos / Vacunas Estafilocócicas / Toxoide Tetánico / Clostridium tetani Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2017 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus / Tétanos / Vacunas Estafilocócicas / Toxoide Tetánico / Clostridium tetani Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2017 Tipo del documento: Article Pais de publicación: Grecia