Desferrioxamine (Desferal) and superoxide free radicals. Formation of an enzyme-damaging nitroxide.
Biochem J
; 246(3): 725-9, 1987 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-2825650
In neutral solutions, desferrioxamine (Desferal) can react with the superoxide free radical, O2.- (possibly through its protonated form HO2.), to form a relatively stable nitroxide free radical, which can have a half-life of approx. 10 min at room temperature. The formation of the radical can be largely prevented by the presence of superoxide dismutase. The radical reacts rapidly with cysteine, methionine, glutathione, vitamin C and a water-soluble derivative of vitamin E. It also reacts rapidly with alcohol dehydrogenase, causing a loss of enzyme activity. The implications of these findings for mechanistic free-radical biochemistry and iron-chelation therapy could be considerable.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Superóxidos
/
Deferoxamina
/
Óxidos de Nitrógeno
Idioma:
En
Revista:
Biochem J
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Reino Unido