Efficient Preparation of Site-Specific Antibody-Drug Conjugates Using Cysteine Insertion.

Dimasi, Nazzareno; Fleming, Ryan; Zhong, Haihong; Bezabeh, Binyam; Kinneer, Krista; Christie, Ronald J; Fazenbaker, Christine; Wu, Herren; Gao, Changshou

Dimasi, Nazzareno; Fleming, Ryan; Zhong, Haihong; Bezabeh, Binyam; Kinneer, Krista; Christie, Ronald J; Fazenbaker, Christine; Wu, Herren; Gao, Changshou.

Afiliación

Dimasi N; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.
Fleming R; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.
Zhong H; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.
Bezabeh B; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.
Kinneer K; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.
Christie RJ; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.
Fazenbaker C; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.
Wu H; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.
Gao C; Antibody Discovery and Protein Engineering and Oncology Research, MedImmune , Gaithersburg, Maryland 20878, United States.

Mol Pharm ; 14(5): 1501-1516, 2017 05 01.

Article en En | MEDLINE | ID: mdl-28245132

Asunto(s)

Anticuerpos Monoclonales/química; Anticuerpos Monoclonales/uso terapéutico; Antineoplásicos/química; Antineoplásicos/uso terapéutico; Cisteína/química; Animales; Anticuerpos Monoclonales Humanizados/química; Anticuerpos Monoclonales Humanizados/uso terapéutico; Línea Celular Tumoral; Femenino; Humanos; Inmunoconjugados/química; Inmunoconjugados/uso terapéutico; Neoplasias Mamarias Experimentales/tratamiento farmacológico; Ratones; Ratones Desnudos; Trastuzumab/química; Trastuzumab/uso terapéutico; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

SG3249; antibody engineering; antibody−drug conjugates; cysteine mutagenesis; cysteine-inserted antibody; oncofetal antigen 5T4; pyrrolobenzodiazepine dimers; site-specific conjugation; tesirine

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cisteína / Anticuerpos Monoclonales / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google