Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma.

Ju, Huai-Qiang; Ying, Haoqiang; Tian, Tian; Ling, Jianhua; Fu, Jie; Lu, Yu; Wu, Min; Yang, Lifeng; Achreja, Abhinav; Chen, Gang; Zhuang, Zhuonan; Wang, Huamin; Nagrath, Deepak; Yao, Jun; Hung, Mien-Chie; DePinho, Ronald A; Huang, Peng; Xu, Rui-Hua; Chiao, Paul J

Ju, Huai-Qiang; Ying, Haoqiang; Tian, Tian; Ling, Jianhua; Fu, Jie; Lu, Yu; Wu, Min; Yang, Lifeng; Achreja, Abhinav; Chen, Gang; Zhuang, Zhuonan; Wang, Huamin; Nagrath, Deepak; Yao, Jun; Hung, Mien-Chie; DePinho, Ronald A; Huang, Peng; Xu, Rui-Hua; Chiao, Paul J.

Afiliación

Ju HQ; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Ying H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Tian T; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Ling J; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Fu J; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Lu Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Wu M; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Yang L; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Achreja A; Laboratory for Systems Biology of Human Diseases, Rice University, Houston, Texas 77005, USA.
Chen G; Laboratory for Systems Biology of Human Diseases, Rice University, Houston, Texas 77005, USA.
Zhuang Z; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Wang H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Nagrath D; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Yao J; Laboratory for Systems Biology of Human Diseases, Rice University, Houston, Texas 77005, USA.
Hung MC; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
DePinho RA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Huang P; The University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA.
Xu RH; The University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA.
Chiao PJ; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Nat Commun ; 8: 14437, 2017 02 24.

Article en En | MEDLINE | ID: mdl-28232723

Asunto(s)

Carcinoma Ductal Pancreático/genética; Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo; NADPH Oxidasa 4/metabolismo; Neoplasias Pancreáticas/genética; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Animales; Carcinoma Ductal Pancreático/metabolismo; Carcinoma Ductal Pancreático/patología; Línea Celular Tumoral; Proliferación Celular/genética; Inhibidor p16 de la Quinasa Dependiente de Ciclina/genética; Pruebas de Enzimas; Perfilación de la Expresión Génica; Regulación Neoplásica de la Expresión Génica; Glucólisis/genética; Humanos; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Transgénicos; Mutación; NADP/metabolismo; NADPH Oxidasas/metabolismo; FN-kappa B/genética; FN-kappa B/metabolismo; Oxidación-Reducción; Páncreas/patología; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patología; Proteínas Proto-Oncogénicas p21(ras)/genética; ARN Interferente Pequeño/metabolismo; Transducción de Señal/genética; Regulación hacia Arriba; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Proto-Oncogénicas p21(ras) / Inhibidor p16 de la Quinasa Dependiente de Ciclina / Carcinoma Ductal Pancreático / NADPH Oxidasa 4 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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