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RAGE polymorphisms and oxidative stress levels in Hashimoto's thyroiditis.
Giannakou, Maria; Saltiki, Katerina; Mantzou, Emily; Loukari, Eleni; Philippou, Georgios; Terzidis, Konstantinos; Lili, Kiriaki; Stavrianos, Charalampos; Kyprianou, Miltiades; Alevizaki, Maria.
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  • Giannakou M; Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece.
  • Saltiki K; Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece.
  • Mantzou E; Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece.
  • Loukari E; Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece.
  • Philippou G; Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece.
  • Terzidis K; Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece.
  • Lili K; Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece.
  • Stavrianos C; Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece.
  • Kyprianou M; Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece.
  • Alevizaki M; Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece.
Eur J Clin Invest ; 47(5): 341-347, 2017 May.
Article en En | MEDLINE | ID: mdl-28226412
BACKGROUND: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been studied in various autoimmune disorders, but not in Hashimoto's thyroiditis. Also, increased oxidative stress has been described in patients with Hashimoto's thyroiditis. The aim of this study was to investigate the possible role of two common RAGE polymorphisms (-429T>C, -374T>A) in Hashimoto's thyroiditis; in parallel, we studied oxidative stress levels. MATERIALS AND METHODS: A total of 300 consecutive euthyroid women were examined and classified into three groups: Hashimoto's thyroiditis with treatment (n = 96), Hashimoto's thyroiditis without treatment (n = 109) and controls (n = 95). For a rough evaluation of oxidative stress, total lipid peroxide levels in serum were measured. The -429T>C AluI and -374T>A MfeI polymorphisms of RAGE were studied in genomic DNA. RESULTS: Significant association of the RAGE system with Hashimoto's thyroiditis was found only with regard to the prevalence of the -429T>C, but not with -374T>A polymorphism. The levels of oxidative stress were significantly elevated in Hashimoto's thyroiditis patients under treatment. Further analysis demonstrated that an oxidative stress cut-off value of 590 µmol/L is associated with an increased risk of progression of Hashimoto's thyroiditis from euthyroidism to hypothyroidism; this risk is further increased in carriers of the RAGE -429T>C polymorphism. CONCLUSIONS: Our findings indicate that both examined risk factors may be implicated in the occurrence of Hashimoto's thyroiditis, but this covers only a fraction of the pathophysiology of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Proteínas Quinasas Activadas por Mitógenos / Enfermedad de Hashimoto / Antígenos de Neoplasias Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Invest Año: 2017 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Proteínas Quinasas Activadas por Mitógenos / Enfermedad de Hashimoto / Antígenos de Neoplasias Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Invest Año: 2017 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido