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Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in ß-cyclodextrin.
Andrade, Tatianny A; Freitas, Thiago S; Araújo, Francielly O; Menezes, Paula P; Dória, Grace Anne A; Rabelo, Alessandra S; Quintans-Júnior, Lucindo J; Santos, Márcio R V; Bezerra, Daniel P; Serafini, Mairim R; Menezes, Irwin Rose A; Nunes, Paula Santos; Araújo, Adriano A S; Costa, Maria S; Campina, Fábia F; Santos, Antonia T L; Silva, Ana R P; Coutinho, Henrique D M.
Afiliación
  • Andrade TA; Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil.
  • Freitas TS; Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil.
  • Araújo FO; Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil.
  • Menezes PP; Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil.
  • Dória GAA; Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil.
  • Rabelo AS; Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil.
  • Quintans-Júnior LJ; Physiology Department, Federal University of Sergipe, Sergipe, Brazil.
  • Santos MRV; Physiology Department, Federal University of Sergipe, Sergipe, Brazil.
  • Bezerra DP; Gonçalo Muniz Research Center, Oswaldo Cruz Foundation, Bahia, Brazil.
  • Serafini MR; Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil.
  • Menezes IRA; Department of Mineralogy and Geotectonics, Institute of Geosciences, University of SãoPaulo-SP, Brazil.
  • Nunes PS; Physiology Department, Federal University of Sergipe, Sergipe, Brazil.
  • Araújo AAS; Pharmacy Department, Federal University of Sergipe, Sergipe, Brazil.
  • Costa MS; Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil.
  • Campina FF; Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil.
  • Santos ATL; Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil.
  • Silva ARP; Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil.
  • Coutinho HDM; Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil. Electronic address: hdmcoutinho@gmail.com.
Biomed Pharmacother ; 89: 201-207, 2017 May.
Article en En | MEDLINE | ID: mdl-28226293
Cyclodextrins (CDs) have been used as important pharmaceutical excipients for improve the physicochemical properties of the drugs of low solubility as the essential oil of Hyptis martiusii. This oil is important therapeutically, but the low solubility and bioavailability compromises your use. Therein, the aim of this study was to obtain and to characterize physico-chemically the samples obtained by physical mixture (PM), paste complexation (PC) and slurry complexation (SC) of the essential oil Hyptis martiusii (EOHM) in ß-CD, and to compare the antibacterial and modulatory-antibiotic activity of products obtained and oil free. The physicochemical characterization was performed by differential scanning calorimetry (DSC), thermogravimetry/derivative thermogravimetry (TG/DTG), scanning electron microscopy (SEM), X-ray diffraction (XRD) and Karl Fischer titration. Additionally, the antibacterial tests were performed by microdilution technique. Thus, it was observed that the PM method showed low complexing capacity, unlike PC and SC in which it was observed the formation of inclusion complexes. In addition, the second stage of the TG/DTG curves showed that SC was the best method inclusion with mass loss of 6.9% over the PC that was 6.0%. The XRD results corroborate with the results above suggesting the formation of new solid phase and the SEM photomicrographs showed the porous surface of the samples PC and SC. The essential oil alone demonstrated an antibacterial and modulatory effect against the S. aureus and the Gram negative strain, respectively. However, the ß-CD and the inclusion complex did not demonstrate any biological activity in the performed antibacterial assays.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites Volátiles / Hyptis / Beta-Ciclodextrinas / Antibacterianos Idioma: En Revista: Biomed Pharmacother Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites Volátiles / Hyptis / Beta-Ciclodextrinas / Antibacterianos Idioma: En Revista: Biomed Pharmacother Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Francia