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Olfactory bulbectomy in mice triggers transient and long-lasting behavioral impairments and biochemical hippocampal disturbances.
Almeida, Roberto Farina de; Ganzella, Marcelo; Machado, Daniele Guilhermano; Loureiro, Samanta Oliveira; Leffa, Douglas; Quincozes-Santos, André; Pettenuzzo, Letícia Ferreira; Duarte, Marta Maria Medeiros Frescura; Duarte, Thiago; Souza, Diogo Onofre.
Afiliación
  • Almeida RF; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: almeida_rf@yahoo.com.br.
  • Ganzella M; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Max Planck Institute for Biophysical Chemistry, Neurobiology Department, Göttingen, Germany. Electronic address: ganzellam@gmail.com.
  • Machado DG; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: dguilhermano@yahoo.com.br.
  • Loureiro SO; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: emaildasamanta@yahoo.com.br.
  • Leffa D; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: douglasleffa@hotmail.com.
  • Quincozes-Santos A; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: andrequincozes@ufrgs.br.
  • Pettenuzzo LF; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: leticiapettenuzzo@gmail.com.
  • Duarte MMMF; Departamento de Ciências da Saúde, Universidade Luterana do Brasil - Campus Santa Maria, RS, Brazil. Electronic address: duartmm@hotmail.com.
  • Duarte T; Departamento de Ciências da Saúde, Universidade Luterana do Brasil - Campus Santa Maria, RS, Brazil. Electronic address: duartethiago89@yahoo.com.br.
  • Souza DO; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: diogo@ufrgs.br.
Prog Neuropsychopharmacol Biol Psychiatry ; 76: 1-11, 2017 06 02.
Article en En | MEDLINE | ID: mdl-28223107
Major depressive disorder (MDD) is a neuropsychiatric disease that is associated with profound disturbances in affected individuals. Elucidating the pathophysiology of MDD has been frustratingly slow, especially concerning the neurochemical events and brain regions associated with disease progression. Thus, we evaluated the time-course (up to 8weeks) behavioral and biochemical effects in mice that underwent to a bilateral olfactory bulbectomy (OBX), which is used to modeling depressive-like behavior in rodents. Similar to the symptoms in patients with MDD, OBX induced long-lasting (e.g., impairment of habituation to novelty, hyperactivity and an anxiety-like phenotype) and transient (e.g., loss of self-care and motivational behavior) behavioral effects. Moreover, OBX temporarily impaired hippocampal synaptosomal mitochondria, in a manner that would be associated with hippocampal-related synaptotoxicity. Finally, long-lasting pro-oxidative (i.e., increased levels of reactive oxygen species and nitric oxide and decreased glutathione levels) and pro-inflammatory (i.e., increased levels of pro-inflammatory cytokines IL-1, IL-6, TNF-α and decreased anti-inflammatory cytokine IL-10 levels) effects were induced in the hippocampus by OBX. Additionally, these parameters were transiently affected in the posterior and frontal cortices. This study is the first to suggest that the transient and long-lasting behavioral effects from OBX strongly correlate with mitochondrial, oxidative and inflammatory parameters in the hippocampus; furthermore, these effects show a weak correlation with these parameters in the cortex. Our findings highlight the underlying mechanisms involved in the biochemical time course of events related to depressive behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Conducta Animal / Trastorno Depresivo Mayor / Hipocampo / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Conducta Animal / Trastorno Depresivo Mayor / Hipocampo / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido