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Ent-Abietanoids Isolated from Isodon serra.
Wan, Jun; Jiang, Hua-Yi; Tang, Jian-Wei; Li, Xing-Ren; Du, Xue; Li, Yan; Sun, Han-Dong; Pu, Jian-Xin.
Afiliación
  • Wan J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. wanjun@imm.ac.cn.
  • Jiang HY; Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China. wanjun@imm.ac.cn.
  • Tang JW; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. jianghuayi@mail.kib.ac.cn.
  • Li XR; Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China. jianghuayi@mail.kib.ac.cn.
  • Du X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. tangjianwei@mail.kib.ac.cn.
  • Li Y; Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China. tangjianwei@mail.kib.ac.cn.
  • Sun HD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. lixingren@mail.kib.ac.cn.
  • Pu JX; Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China. lixingren@mail.kib.ac.cn.
Molecules ; 22(2)2017 Feb 17.
Article en En | MEDLINE | ID: mdl-28218684
Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3α,14ß)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 µM) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Isodon / Abietanos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Isodon / Abietanos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza