Human Th17 Migration in Three-Dimensional Collagen Involves p38 MAPK.
J Cell Biochem
; 118(9): 2819-2827, 2017 09.
Article
en En
| MEDLINE
| ID: mdl-28198034
T cell migration across extracellular matrix (ECM) is an important step of the adaptive immune response but is also involved in the development of inflammatory autoimmune diseases. Currently, the molecular mechanisms regulating the motility of effector T cells in ECM are not fully understood. Activation of p38 MAPK has been implicated in T cell activation and is critical to the development of immune and inflammatory responses. In this study, we examined the implication of p38 MAPK in regulating the migration of human Th17 cells through collagen. Using specific inhibitor and siRNA, we found that p38 is necessary for human Th17 migration in three-dimensional (3D) collagen and that 3D collagen increases p38 phosphorylation. We also provide evidence that the collagen receptor, discoidin domain receptor 1 (DDR1), which promotes Th17 migration in 3D collagen, is involved in p38 activation. Together, our findings suggest that targeting DDR1/p38 MAPK pathway could be beneficial for the treatment of Th17-mediated inflammatory diseases. J. Cell. Biochem. 118: 2819-2827, 2017. © 2017 Wiley Periodicals, Inc.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Movimiento Celular
/
Colágeno
/
Sistema de Señalización de MAP Quinasas
/
Proteínas Quinasas p38 Activadas por Mitógenos
/
Células Th17
Límite:
Humans
Idioma:
En
Revista:
J Cell Biochem
Año:
2017
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos