Your browser doesn't support javascript.
loading
Tandem emulsification for high-throughput production of double emulsions.
Eggersdorfer, M L; Zheng, W; Nawar, S; Mercandetti, C; Ofner, A; Leibacher, I; Koehler, S; Weitz, D A.
Afiliación
  • Eggersdorfer ML; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. weitz@seas.harvard.edu.
  • Zheng W; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Nawar S; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. weitz@seas.harvard.edu.
  • Mercandetti C; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. weitz@seas.harvard.edu.
  • Ofner A; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. weitz@seas.harvard.edu.
  • Leibacher I; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. weitz@seas.harvard.edu.
  • Koehler S; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. weitz@seas.harvard.edu.
  • Weitz DA; School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. weitz@seas.harvard.edu and Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.
Lab Chip ; 17(5): 936-942, 2017 02 28.
Article en En | MEDLINE | ID: mdl-28197593
Core-shell double emulsions produced using microfluidic methods with controlled structural parameters exhibit great potential in a wide range of applications, but the low production rate of microfluidic methods hinders the exploitation of the capabilities of microfluidics to produce double emulsions with well-defined features. A major obstacle towards the scaled-up production of core-shell double emulsions is the difficulty of achieving robust spatially controlled wettability in integrated microfluidic devices. Here, we use tandem emulsification, a two-step process with microfluidic devices, to scale up the production. With this method, single emulsions are generated in a first device and are re-injected directly into a second device to form uniform double emulsions. We demonstrate the application of tandem emulsification for scalable core-shell emulsion production with both integrated flow focusing and millipede devices and obtain emulsions of which over 90% are single-core monodisperse double emulsion drops. With both mechanisms, the shell thickness can be controlled, so that shells as thin as 3 µm are obtained for emulsions 50 µm in radius.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Lab Chip Asunto de la revista: BIOTECNOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Lab Chip Asunto de la revista: BIOTECNOLOGIA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido