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A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.
Wiemerslage, L; Islam, R; van der Kamp, C; Cao, H; Olivo, G; Ence-Eriksson, F; Castillo, S; Larsen, A L; Bandstein, M; Dahlberg, L S; Perland, E; Gustavsson, V; Nilsson, J; Vogel, H; Schürmann, A; Larsson, E-M; Rask-Andersen, M; Benedict, C; Schiöth, H B.
Afiliación
  • Wiemerslage L; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Islam R; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • van der Kamp C; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Cao H; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Olivo G; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Ence-Eriksson F; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Castillo S; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Larsen AL; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Bandstein M; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Dahlberg LS; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Perland E; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Gustavsson V; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Nilsson J; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Vogel H; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Schürmann A; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
  • Larsson EM; Radiology Unit, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Rask-Andersen M; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Benedict C; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
  • Schiöth HB; Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala Sweden.
Int J Obes (Lond) ; 41(6): 990-994, 2017 06.
Article en En | MEDLINE | ID: mdl-28194012
We investigated five methylation markers recently linked to body mass index, for their role in the neuropathology of obesity. In neuroimaging experiments, our analysis involving 23 participants showed that methylation levels for the cg07814318 site, which lies within the KLF13 gene, correlated with brain activity in the claustrum, putamen, cingulate gyrus and frontal gyri, some of which have been previously associated to food signaling, obesity or reward. Methylation levels at cg07814318 also positively correlated with ghrelin levels. Moreover, expression of KLF13 was augmented in the brains of obese and starved mice. Our results suggest the cg07814318 site could be involved in orexigenic processes, and also implicate KLF13 in obesity. Our findings are the first to associate methylation levels in blood with brain activity in obesity-related regions, and further support previous findings between ghrelin, brain activity and genetic differences.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Proteínas de Ciclo Celular / Metilación de ADN / Factores de Transcripción de Tipo Kruppel / Ghrelina / Orexinas / Neuronas / Obesidad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Int J Obes (Lond) Asunto de la revista: METABOLISMO Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Proteínas de Ciclo Celular / Metilación de ADN / Factores de Transcripción de Tipo Kruppel / Ghrelina / Orexinas / Neuronas / Obesidad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Int J Obes (Lond) Asunto de la revista: METABOLISMO Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido