Polyphenols rich Passiflora leschenaultii leaves modulating Farnesoid X Receptor and Pregnane X Receptor against paracetamol-induced hepatotoxicity in rats.

Shanmugam, Saravanan; Sivaraj, Dhivya; Dos Santos Lima, Bruno; Dos Passos Menezes, Paula; de Carvalho, Yasmim Maria Barbosa Gomes; de Souza Araújo, Adriano Antunes; Narain, Narendra; Serafini, Mairim Russo; Quintans Júnior, Lucindo José; Scotti, Luciana; Scotti, Marcus Tulius; Parimelazhagan, Thangaraj

Shanmugam, Saravanan; Sivaraj, Dhivya; Dos Santos Lima, Bruno; Dos Passos Menezes, Paula; de Carvalho, Yasmim Maria Barbosa Gomes; de Souza Araújo, Adriano Antunes; Narain, Narendra; Serafini, Mairim Russo; Quintans Júnior, Lucindo José; Scotti, Luciana; Scotti, Marcus Tulius; Parimelazhagan, Thangaraj.

Afiliación

Shanmugam S; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil. Electronic address: saranflora04@gmail.com.
Sivaraj D; Bioprospecting laboratory, Department of Botany, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India.
Dos Santos Lima B; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
Dos Passos Menezes P; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
de Carvalho YMBG; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
de Souza Araújo AA; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil. Electronic address: adriasa2001@yahoo.com.br.
Narain N; Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
Serafini MR; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
Quintans Júnior LJ; Department of Pharmacy, Federal University of Sergipe, CEP, 49100-000, Sao Cristovao, Brazil.
Scotti L; Department of Chemistry, Federal University of Paraíba, Joao Pessoa, Paraíba, CEP, 58051900, Brazil.
Scotti MT; Department of Chemistry, Federal University of Paraíba, Joao Pessoa, Paraíba, CEP, 58051900, Brazil.
Parimelazhagan T; Bioprospecting laboratory, Department of Botany, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India. Electronic address: drparimel@gmail.com.

Biomed Pharmacother ; 88: 1114-1121, 2017 Apr.

Article en En | MEDLINE | ID: mdl-28192885

Asunto(s)

Acetaminofén/efectos adversos; Hepatopatías/tratamiento farmacológico; Passiflora/química; Hojas de la Planta/química; Polifenoles/uso terapéutico; Receptores Citoplasmáticos y Nucleares/metabolismo; Receptores de Esteroides/metabolismo; Animales; Antioxidantes/metabolismo; Biomarcadores/sangre; Peso Corporal/efectos de los fármacos; Hepatopatías/sangre; Hepatopatías/enzimología; Masculino; Simulación del Acoplamiento Molecular; Tamaño de los Órganos/efectos de los fármacos; Extractos Vegetales/farmacología; Extractos Vegetales/uso terapéutico; Polifenoles/química; Receptor X de Pregnano; Sustancias Protectoras/farmacología; Sustancias Protectoras/uso terapéutico; Ratas Wistar; Silimarina/farmacología; Silimarina/uso terapéutico

Palabras clave

Caffeic acid; FXR; Hepatoprotective; PXR; Paracetamol; Rutin

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Esteroides / Receptores Citoplasmáticos y Nucleares / Hojas de la Planta / Passiflora / Polifenoles / Hepatopatías / Acetaminofén Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2017 Tipo del documento: Article Pais de publicación: Francia

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google