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Correlation between the high-frequency content of the QRS on murine surface electrocardiogram and the sympathetic nerves density in left ventricle after myocardial infarction: Experimental study.
Sedaghat, Golriz; Gardner, Ryan T; Kabir, Muammar M; Ghafoori, Elyar; Habecker, Beth A; Tereshchenko, Larisa G.
Afiliación
  • Sedaghat G; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA; Portland State University, Portland, OR, USA.
  • Gardner RT; Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA.
  • Kabir MM; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.
  • Ghafoori E; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA; University of Utah, Salt Lake City, UT, USA.
  • Habecker BA; Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA.
  • Tereshchenko LG; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: tereshch@ohsu.edu.
J Electrocardiol ; 50(3): 323-331, 2017.
Article en En | MEDLINE | ID: mdl-28190561
Denervated post-infarct scar is arrhythmogenic. Our aim was to compare QRS frequency content in denervated and innervated left ventricular (LV) scar. In-vivo single lead ECG telemetry device was implanted in 17 heterozygous PTPσ (HET) and 7 lacking PTPσ (KO) transgenic mice. Myocardial infarction (MI) with reperfusion and sham surgery was performed. HET mice developed a denervated scar, whereas KO mice developed innervated scar. The power spectral density was used to assess the QRS frequency content. Denervated as compared to innervated post-MI scar was characterized by the higher relative contribution of 300-500 Hz (14 ± 1 vs. 9 ± 1%; P = 0.001) but reduced relative contribution of 200-300 Hz (86 ± 1 vs. 91 ± 1%; P = 0.001). Norepinephrine concentration in peri-infarct zone correlated with both 1-200 Hz (r = 0.75; P = 0.03) and 200-500 Hz QRS power (r = 0.73; P = 0.04). Sympathetic fiber density within the infarct correlated with 200-300/200-500 Hz QRS power ratio (r = 0.56; P = 0.005). Intracellular sigma peptide injections in post-MI HET mice restored the QRS power.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Simpático / Aturdimiento Miocárdico / Electroencefalografía / Sistema de Conducción Cardíaco / Ventrículos Cardíacos / Infarto del Miocardio Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Animals Idioma: En Revista: J Electrocardiol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Simpático / Aturdimiento Miocárdico / Electroencefalografía / Sistema de Conducción Cardíaco / Ventrículos Cardíacos / Infarto del Miocardio Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Animals Idioma: En Revista: J Electrocardiol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos