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A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence.
Alexander, Peter D; Gicas, Kristina M; Willi, Taylor S; Kim, Clara N; Boyeva, Veronika; Procyshyn, Ric M; Smith, Geoff N; Thornton, Allen E; Panenka, William J; Jones, Andrea A; Vila-Rodriguez, Fidel; Lang, Donna J; William MacEwan, G; Honer, William G; Barr, Alasdair M.
Afiliación
  • Alexander PD; Department of Pharmacology, 2176 Health Sciences Mall, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Gicas KM; Department of Psychology, Simon Fraser University, Burnaby, B.C., V5A 1S6, Canada.
  • Willi TS; Department of Psychology, Simon Fraser University, Burnaby, B.C., V5A 1S6, Canada.
  • Kim CN; Department of Pharmacology, 2176 Health Sciences Mall, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Boyeva V; Department of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Procyshyn RM; Department of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Smith GN; Department of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Thornton AE; Department of Psychology, Simon Fraser University, Burnaby, B.C., V5A 1S6, Canada.
  • Panenka WJ; Department of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Jones AA; Department of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Vila-Rodriguez F; Department of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Lang DJ; Department of Radiology, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • William MacEwan G; Department of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Honer WG; Department of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
  • Barr AM; Department of Pharmacology, 2176 Health Sciences Mall, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada. al.barr@ubc.ca.
Psychopharmacology (Berl) ; 234(9-10): 1535-1547, 2017 05.
Article en En | MEDLINE | ID: mdl-28190084
RATIONALE: The psychostimulant drugs cocaine and methamphetamine are potent indirect dopamine receptor agonists which act through similar but not identical mechanisms. Studies in humans have observed that a large proportion of those who chronically use these drugs experience psychotic symptoms. However, direct comparisons of psychotic symptom severity between cocaine and methamphetamine users are lacking. OBJECTIVES: The goal of the present study was to directly compare severity of psychotic symptoms between cocaine- and methamphetamine-dependent individuals. Additionally, we sought to determine how concurrent cocaine + methamphetamine dependence would influence psychotic symptoms. METHODS: We recruited 153 polysubstance-using subjects meeting DSM-IV-TR criteria for cocaine dependence, 38 with methamphetamine dependence, and 32 with cocaine + methamphetamine dependence. Psychotic symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) and analyzed using a five-factor model. All participants were also assessed for physical and mental illnesses as well as recent substance use. Most subjects completed a comprehensive neurocognitive battery. RESULTS: While all three groups exhibited high total PANSS scores, the positive symptom subscale was significantly higher in the methamphetamine-dependent (17.03 ± 6.3) than the cocaine-dependent group (13.51 ± 4.12) and non-significantly higher (p = 0.08) than the cocaine + methamphetamine group (14.44 ± 5.50). Groups also differed on demographic variables, viral infection, and other indices of substance use, which were unlikely to account for the difference in positive symptoms. There were only modest differences between groups in neurocognitive function. CONCLUSIONS: Methamphetamine dependence was associated with more severe positive symptoms of psychosis than cocaine dependence. Concurrent cocaine + methamphetamine dependence did not increase psychosis severity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicosis Inducidas por Sustancias / Trastornos Relacionados con Anfetaminas / Trastornos Relacionados con Cocaína / Metanfetamina Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychopharmacology (Berl) Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicosis Inducidas por Sustancias / Trastornos Relacionados con Anfetaminas / Trastornos Relacionados con Cocaína / Metanfetamina Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychopharmacology (Berl) Año: 2017 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania