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3-(2-deoxy-ß-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers.
Bonassi, Stefano; Cellai, Filippo; Munnia, Armelle; Ugolini, Donatella; Cristaudo, Alfonso; Neri, Monica; Milic, Mirta; Bonotti, Alessandra; Giese, Roger W; Peluso, Marco E M.
Afiliación
  • Bonassi S; Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Rome, Italy; Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Rome, Italy.
  • Cellai F; Cancer Risk Factor Branch, Regional Cancer Prevention Laboratory, ISPO-Cancer Prevention and Research Institute, Florence, Italy.
  • Munnia A; Cancer Risk Factor Branch, Regional Cancer Prevention Laboratory, ISPO-Cancer Prevention and Research Institute, Florence, Italy.
  • Ugolini D; Department of Internal Medicine, University of Genoa and IRCSS AOU San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
  • Cristaudo A; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Occupational Medicine Unit, University of Pisa, Pisa, Italy.
  • Neri M; Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Rome, Italy.
  • Milic M; Mutagenesis Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.
  • Bonotti A; Occupational Medicine Unit, University of Pisa, Pisa, Italy.
  • Giese RW; Department of Pharmaceutical Sciences in the Bouve College of Health Sciences, Barnett Institute, Northeastern University, Boston, MA, United States.
  • Peluso ME; Cancer Risk Factor Branch, Regional Cancer Prevention Laboratory, ISPO-Cancer Prevention and Research Institute, Florence, Italy. Electronic address: m.peluso@ispo.toscana.it.
Toxicol Lett ; 270: 1-7, 2017 Mar 15.
Article en En | MEDLINE | ID: mdl-28188891
Asbestos is the commercial name for a group of silicate minerals naturally occurring in the environment and widely used in the industry. Asbestos exposure has been associated with pulmonary fibrosis, mesothelioma, and malignancies, which may appear after a period of latency of 20-40 years. Mechanisms involved in the carcinogenic effects of asbestos are still not fully elucidated, although the oxidative stress theory suggests that phagocytic cells produce large amounts of reactive oxygen species, due to their inability to digest asbestos fiber. We have conducted a mechanistic study to evaluate the association between 3-(2-deoxy-ß-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, a biomarker of oxidative stress and lipid peroxidation, and asbestos exposure in the peripheral blood of 327 subjects living in Tuscany and Liguria, Italy, stratified by occupational exposure to asbestos. Adduct frequency was significantly greater into exposed subjects with respect to the controls. M1dG per 108 normal nucleotides were 4.0±0.5 (SE) in 156 asbestos workers, employed in mechanic, naval, petrochemical, building industries, and in pottery and ceramic plants, versus a value of 2.3±0.1 (SE) in 171 controls (p<0.001). After stratification for occupational history, the effects persisted in 54 current asbestos workers, mainly employed in building renovation industry (2.9±0.3 (SE)), and in 102 former asbestos workers (4.5±0.7 (SE)), with p-values of 0.033, and <0.001, respectively. A significant effect of smoking on heavy smokers was found (p=0.005). Our study gives additional support to the oxidative stress theory, where M1dG may reflect an additional potential mechanism of asbestos-induced toxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Amianto / Nucleósidos de Purina / Exposición Profesional / Aductos de ADN / Desoxiguanosina Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Toxicol Lett Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Amianto / Nucleósidos de Purina / Exposición Profesional / Aductos de ADN / Desoxiguanosina Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Toxicol Lett Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos