Your browser doesn't support javascript.
loading
A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline.
Levin, B J; Huang, Y Y; Peck, S C; Wei, Y; Martínez-Del Campo, A; Marks, J A; Franzosa, E A; Huttenhower, C; Balskus, E P.
Afiliación
  • Levin BJ; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
  • Huang YY; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
  • Peck SC; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
  • Wei Y; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
  • Martínez-Del Campo A; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
  • Marks JA; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
  • Franzosa EA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
  • Huttenhower C; Broad Institute, Cambridge, MA 02139, USA.
  • Balskus EP; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Science ; 355(6325)2017 02 10.
Article en En | MEDLINE | ID: mdl-28183913
The human microbiome encodes vast numbers of uncharacterized enzymes, limiting our functional understanding of this community and its effects on host health and disease. By incorporating information about enzymatic chemistry into quantitative metagenomics, we determined the abundance and distribution of individual members of the glycyl radical enzyme superfamily among the microbiomes of healthy humans. We identified many uncharacterized family members, including a universally distributed enzyme that enables commensal gut microbes and human pathogens to dehydrate trans-4-hydroxy-l-proline, the product of the most abundant human posttranslational modification. This "chemically guided functional profiling" workflow can therefore use ecological context to facilitate the discovery of enzymes in microbial communities.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolina Oxidasa / Tracto Gastrointestinal / Microbioma Gastrointestinal / Hidroxiprolina Límite: Humans Idioma: En Revista: Science Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolina Oxidasa / Tracto Gastrointestinal / Microbioma Gastrointestinal / Hidroxiprolina Límite: Humans Idioma: En Revista: Science Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos