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Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles.
Dias, Cintia B; Amigó, Núria; Wood, Lisa G; Mallol, Roger; Correig, Xavier; Garg, Manohar L.
Afiliación
  • Dias CB; Nutraceuticals Research Group, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address: cintia.dias@uon.edu.au.
  • Amigó N; Metabolomics Platform, Rovira i Virgili University, IISPV, Avinguda Països Catalans 26, 43007 Tarragona, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), C/ Monforte de Lemos 3-5, 28029, Madrid, Spain; Biosfer Teslab, Plaça Prim 10, 2on 5a, 43201 R
  • Wood LG; Centre for Asthma and Respiratory Disease, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address: lisa.wood@newcastle.edu.au.
  • Mallol R; Biosfer Teslab, Plaça Prim 10, 2on 5a, 43201 Reus, Spain. Electronic address: rmallol@biosferteslab.com.
  • Correig X; Metabolomics Platform, Rovira i Virgili University, IISPV, Avinguda Països Catalans 26, 43007 Tarragona, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), C/ Monforte de Lemos 3-5, 28029, Madrid, Spain. Electronic address: xavier.correig@urv.cat.
  • Garg ML; Nutraceuticals Research Group, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address: manohar.garg@newcastle.edu.au.
Metabolism ; 68: 11-19, 2017 Mar.
Article en En | MEDLINE | ID: mdl-28183443
BACKGROUND AND AIMS: Dietary fat composition is known to modulate circulating lipid and lipoprotein levels. Although supplementation with long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to reduce plasma triglyceride levels, the effect of the interactions between LCn-3PUFA and the major dietary fats consumed has not been previously investigated. METHODS: In a randomized controlled parallel design clinical intervention, we examined the effect of diets rich in either saturated fatty acids (SFA) or omega-6 polyunsaturated fatty acids (n-6PUFA) on plasma lipid levels and lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) in subjects with an adequate omega 3 index. Twenty six healthy subjects went through a four-week pre-supplementation period with LCn-3PUFA and were then randomized to diets rich in either n-6PUFA or SFA both supplemented with LCn-3PUFA. RESULTS: The diet rich in n-6PUFA decreased low density lipoprotein (LDL) particle concentration (-8%, p=0.013) and LDL cholesterol (LDL-C) level (-8%, p=0.021), while the saturated fat rich diet did not affect LDL particle concentration or LDL-C levels significantly. Nevertheless, dietary saturated fatty acids increased LCn-3PUFA in plasma and tissue lipids compared with n-6PUFA, potentially reducing other cardiovascular risk factors such as inflammation and clotting tendency. CONCLUSION: Improvement on the omega 3 index of healthy subjects did not alter the known effects of dietary saturated fats and n-6PUFA on LDL profiles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Grasas de la Dieta / Ácidos Grasos Omega-3 / Ácidos Grasos / Ácidos Grasos Insaturados / Lipoproteínas LDL / LDL-Colesterol Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Metabolism Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Grasas de la Dieta / Ácidos Grasos Omega-3 / Ácidos Grasos / Ácidos Grasos Insaturados / Lipoproteínas LDL / LDL-Colesterol Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Metabolism Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos