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Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells.
Arpón, A; Riezu-Boj, J I; Milagro, F I; Marti, A; Razquin, C; Martínez-González, M A; Corella, D; Estruch, R; Casas, R; Fitó, M; Ros, E; Salas-Salvadó, J; Martínez, J A.
Afiliación
  • Arpón A; Department of Nutrition, Food Sciences and Physiology, Universidad de Navarra, Irunlarrea 1, 31009, Pamplona, Spain.
  • Riezu-Boj JI; Centre for Nutrition Research, Universidad de Navarra, Irunlarrea 1, 31009, Pamplona, Spain.
  • Milagro FI; Department of Nutrition, Food Sciences and Physiology, Universidad de Navarra, Irunlarrea 1, 31009, Pamplona, Spain.
  • Marti A; Centre for Nutrition Research, Universidad de Navarra, Irunlarrea 1, 31009, Pamplona, Spain.
  • Razquin C; Navarra Institute for Health Research (IdiSNa), Pamplona, Spain.
  • Martínez-González MA; Department of Nutrition, Food Sciences and Physiology, Universidad de Navarra, Irunlarrea 1, 31009, Pamplona, Spain.
  • Corella D; Centre for Nutrition Research, Universidad de Navarra, Irunlarrea 1, 31009, Pamplona, Spain.
  • Estruch R; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain.
  • Casas R; Department of Nutrition, Food Sciences and Physiology, Universidad de Navarra, Irunlarrea 1, 31009, Pamplona, Spain.
  • Fitó M; Navarra Institute for Health Research (IdiSNa), Pamplona, Spain.
  • Ros E; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain.
  • Salas-Salvadó J; Navarra Institute for Health Research (IdiSNa), Pamplona, Spain.
  • Martínez JA; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain.
J Physiol Biochem ; 73(3): 445-455, 2016 Aug.
Article en En | MEDLINE | ID: mdl-28181167
Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells. A subset of 36 individuals was selected within the Prevención con Dieta Mediterránea (PREDIMED)-Navarra study, a randomised, controlled, parallel trial with three groups of intervention in high cardiovascular risk volunteers, two with a MedDiet and one low-fat control group. Changes in methylation between baseline and 5 years were studied. DNA methylation arrays were analysed by several robust statistical tests and functional classifications. Eight genes related to inflammation and immunocompetence (EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1, MAPKAPK2, PPARGC1B) were finally selected as changes in their methylation levels correlated with adherence to MedDiet and because they presented sensitivity related to a high variability in methylation changes. Additionally, EEF2 methylation levels positively correlated with concentrations of TNF-α and CRP. This report is apparently the first showing that adherence to MedDiet is associated with the methylation of the reported genes related to inflammation with a potential regulatory impact.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dieta Mediterránea / Diabetes Mellitus Tipo 2 / Leucocitos Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: España Pais de publicación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dieta Mediterránea / Diabetes Mellitus Tipo 2 / Leucocitos Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: España Pais de publicación: España