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Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease.
Gray, Stephen P; Jha, Jay C; Kennedy, Kit; van Bommel, Erik; Chew, Phyllis; Szyndralewiez, Cedric; Touyz, Rhian M; Schmidt, Harald H H W; Cooper, Mark E; Jandeleit-Dahm, Karin A M.
Afiliación
  • Gray SP; Diabetic Complications Division, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Rd, Melbourne, VIC, 8008, Australia. stephen.gray@bakeridi.edu.au.
  • Jha JC; Faculty of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia. stephen.gray@bakeridi.edu.au.
  • Kennedy K; Diabetic Complications Division, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Rd, Melbourne, VIC, 8008, Australia.
  • van Bommel E; Diabetic Complications Division, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Rd, Melbourne, VIC, 8008, Australia.
  • Chew P; Diabetic Complications Division, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Rd, Melbourne, VIC, 8008, Australia.
  • Szyndralewiez C; Diabetic Complications Division, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Rd, Melbourne, VIC, 8008, Australia.
  • Touyz RM; Genkyotex SA, Geneva, Switzerland.
  • Schmidt HHHW; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Cooper ME; Department of Pharmacology, Faculty of Medicine, Health & Life Science, Maastricht University, Maastricht, the Netherlands.
  • Jandeleit-Dahm KAM; Cardiovascular Research Institute Maastricht (CARIM), Faculty of Medicine, Health & Life Science, Maastricht University, Maastricht, the Netherlands.
Diabetologia ; 60(5): 927-937, 2017 05.
Article en En | MEDLINE | ID: mdl-28160092
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Piridinas / NADPH Oxidasas / Complicaciones de la Diabetes / Diabetes Mellitus Experimental / NADH NADPH Oxidorreductasas Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Diabetologia Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Piridinas / NADPH Oxidasas / Complicaciones de la Diabetes / Diabetes Mellitus Experimental / NADH NADPH Oxidorreductasas Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Diabetologia Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania