ß-Caryophyllene/Hydroxypropyl-ß-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway.
Front Pharmacol
; 8: 2, 2017.
Article
en En
| MEDLINE
| ID: mdl-28154534
This work was conducted to prepare ß-caryophyllene-hydroxypropyl-ß-cyclodextrin inclusion complex (HPßCD/BCP) and investigate its effects and mechanisms on cognitive deficits in vascular dementia (VD) rats. First, HPßCD/BCP was prepared, optimized, characterized, and evaluated. HPßCD/BCP and AM630 were then administered to VD rats to upregulate and downregulate the cannabinoid receptor type 2 (CB2). Results showed that HPßCD/BCP can significantly increase the bioavailability of BCP. Through the Morris water maze test, HPßCD/BCP can attenuate learning and memory deficits in rats. Cerebral blood flow (CBF) monitoring results indicated that HPßCD/BCP can promote the recovery of CBF. Moreover, molecular biology experiments showed that HPßCD/BCP can increase the expression levels of CB2 in brain tissues, particularly the hippocampus and white matter tissues, as well as the expression levels of PI3K and Akt. Overall, the findings demonstrated the protective effects of HPßCD/BCP against cognitive deficits induced by chronic cerebral ischemia and suggested the potential of HPßCD/BCP in the therapy of vascular dementia in the future.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Front Pharmacol
Año:
2017
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Suiza