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Mean cerebral blood volume is an effective diagnostic index of recurrent and radiation injury in glioma patients: A meta-analysis of diagnostic test.
Li, Zhanzhan; Zhou, Qin; Li, Yanyan; Yan, Shipeng; Fu, Jun; Huang, Xinqiong; Shen, Liangfang.
Afiliación
  • Li Z; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
  • Zhou Q; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
  • Li Y; Office of Cancer Prevent and Control, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
  • Yan S; Office of Cancer Prevent and Control, Hunan Provincial Tumor Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013 China.
  • Fu J; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
  • Huang X; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
  • Shen L; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Oncotarget ; 8(9): 15642-15650, 2017 Feb 28.
Article en En | MEDLINE | ID: mdl-28152505
We conducted a meta-analysis to evaluate the diagnostic values of mean cerebral blood volume for recurrent and radiation injury in glioma patients. We performed systematic electronic searches for eligible study up to August 8, 2016. Bivariate mixed effects models were used to estimate the combined sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, diagnostic odds ratios and their 95% confidence intervals (CIs). Fifteen studies with a total number of 576 participants were enrolled. The pooled sensitivity and specificity of diagnostic were 0.88 (95%CI: 0.82-0.92) and 0.85 (95%CI: 0.68-0.93). The pooled positive likelihood ratio is 5.73 (95%CI: 2.56-12.81), negative likelihood ratio is 0.15 (95%CI: 0.10-0.22), and the diagnostic odds ratio is 39.34 (95%CI:13.96-110.84). The summary receiver operator characteristic is 0.91 (95%CI: 0.88-0.93). However, the Deek's plot suggested publication bias may exist (t=2.30, P=0.039). Mean cerebral blood volume measurement methods seems to be very sensitive and highly specific to differentiate recurrent and radiation injury in glioma patients. The results should be interpreted with caution because of the potential bias.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Radioterapia / Quimioradioterapia / Volumen Sanguíneo Cerebral / Glioma Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Radioterapia / Quimioradioterapia / Volumen Sanguíneo Cerebral / Glioma Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos