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The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases.
Eckei, Laura; Krieg, Sarah; Bütepage, Mareike; Lehmann, Anne; Gross, Annika; Lippok, Barbara; Grimm, Alexander R; Kümmerer, Beate M; Rossetti, Giulia; Lüscher, Bernhard; Verheugd, Patricia.
Afiliación
  • Eckei L; Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany.
  • Krieg S; Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany.
  • Bütepage M; Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany.
  • Lehmann A; Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany.
  • Gross A; Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany.
  • Lippok B; Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52057 Aachen, Germany.
  • Grimm AR; Institute of Biotechnology, RWTH Aachen University, 52074 Aachen, Germany.
  • Kümmerer BM; Institute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany.
  • Rossetti G; Computational Biomedicine, Institute for Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich, 52425, Jülich, Germany.
  • Lüscher B; Jülich Supercomputing Centre, Forschungszentrum Jülich, 52425, Jülich, Germany.
  • Verheugd P; Department of Oncology, Hematology and Stem Cell Transplantation, Medical School, RWTH Aachen University, Aachen, Germany.
Sci Rep ; 7: 41746, 2017 02 02.
Article en En | MEDLINE | ID: mdl-28150709
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus ARN / Virus Chikungunya / Proteínas Proto-Oncogénicas / Poli(ADP-Ribosa) Polimerasas / Proteínas no Estructurales Virales Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus ARN / Virus Chikungunya / Proteínas Proto-Oncogénicas / Poli(ADP-Ribosa) Polimerasas / Proteínas no Estructurales Virales Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido