Your browser doesn't support javascript.
loading
Acoustic startle response in rats predicts inter-individual variation in fear extinction.
Russo, Amanda S; Parsons, Ryan G.
Afiliación
  • Russo AS; Stony Brook University, Department of Psychology, 100 Nicolls Rd., Stony Brook, NY 11794, United States.
  • Parsons RG; Stony Brook University, Department of Psychology, 100 Nicolls Rd., Stony Brook, NY 11794, United States; Neurosciences Institute, 100 Nicolls Rd., Stony Brook, NY 11794, United States. Electronic address: ryan.parsons@stonybrook.edu.
Neurobiol Learn Mem ; 139: 157-164, 2017 Mar.
Article en En | MEDLINE | ID: mdl-28131759
Although a large portion of the population is exposed to a traumatic event at some point, only a small percentage of the population develops post-traumatic stress disorder (PTSD), suggesting the presence of predisposing factors. Abnormal acoustic startle response (ASR) has been shown to be associated with PTSD, implicating it as a potential predictor of the development of PTSD-like behavior. Since poor extinction and retention of extinction learning are characteristic of PTSD patients, it is of interest to determine if abnormal ASR is predictive of development of such deficits. To determine whether baseline ASR has utility in predicting the development of PTSD-like behavior, the relationship between baseline ASR and freezing behavior following Pavlovian fear conditioning was examined in a group of adult, male Sprague-Dawley rats. Baseline acoustic startle response (ASR) was assessed preceding exposure to a Pavlovian fear conditioning paradigm where freezing behavior was measured during fear conditioning, extinction training, and extinction testing. Although there was no relationship between baseline ASR and fear memory following conditioning, rats with low baseline ASR had significantly lower magnitude of retention of the extinction memory than rats with high baseline ASR. The results suggest that baseline ASR has value as a predictive index of the development of a PTSD-like phenotype.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reflejo de Sobresalto / Condicionamiento Clásico / Extinción Psicológica / Miedo / Individualidad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Neurobiol Learn Mem Asunto de la revista: BIOLOGIA / CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reflejo de Sobresalto / Condicionamiento Clásico / Extinción Psicológica / Miedo / Individualidad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Neurobiol Learn Mem Asunto de la revista: BIOLOGIA / CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos