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[Epidemiology and pharmacoepidemiology of immune thrombocytopenia]. / Épidémiologie et pharmacoépidémiologie du purpura thrombopénique immunologique.
Moulis, G; Lapeyre-Mestre, M; Adoue, D; Sailler, L.
Afiliación
  • Moulis G; Service de médecine interne, salle Le Tallec, pavillon URM, CHU Purpan, place du Dr-Baylac, TSA 40031, 31059 Toulouse cedex 9, France; UMR 1027 Inserm, université de Toulouse, faculté de médecine, 37, allées Jules-Guesde, 31000 Toulouse, France; CIC 1436, CHU de Toulouse, CHU Purpan, place du Dr-Bay
  • Lapeyre-Mestre M; UMR 1027 Inserm, université de Toulouse, faculté de médecine, 37, allées Jules-Guesde, 31000 Toulouse, France; CIC 1436, CHU de Toulouse, CHU Purpan, place du Dr-Baylac, TSA 40031, 31059 Toulouse cedex 9, France; Service de pharmacologie médicale et clinique, CHU de Toulouse, faculté de médecine, 37
  • Adoue D; Service de médecine interne, institut universitaire du cancer de Toulouse-Oncopôle, 1, avenue Irène-Joliot-Curie, 31100 Toulouse, France.
  • Sailler L; Service de médecine interne, salle Le Tallec, pavillon URM, CHU Purpan, place du Dr-Baylac, TSA 40031, 31059 Toulouse cedex 9, France; UMR 1027 Inserm, université de Toulouse, faculté de médecine, 37, allées Jules-Guesde, 31000 Toulouse, France; CIC 1436, CHU de Toulouse, CHU Purpan, place du Dr-Bay
Rev Med Interne ; 38(7): 444-449, 2017 Jul.
Article en Fr | MEDLINE | ID: mdl-28131440
During the last decade, the development of large clinical and population-based cohorts led to new findings in the epidemiology and the pharmacoepidemiology of immune thrombocytopenia (ITP). The incidence is estimated to 3-4 for 105 inhabitants/year, with a slight female predominance and peaks in children and patients after 60 years. The incidence rate is 9 for 105 inhabitants/year in males after 75 years. Variations across ethnic groups are discussed. In France, there is a North-South gradient and a peak of incidence during winter suggesting the role of viruses in ITP pathophysiology. Myelodysplastic syndromes are an emergent cause of secondary ITP. The incidence of intracranial bleeding is about 1% by year and the risk increases with aging. Exposure to splenectomy decreases while rituximab and thrombopoietin receptor agonists (TPO-RA) are the most used second-line drugs for persistent ITP. Mortality is slightly increased in primary ITP as compared with the general population. ITP patients have an increased risk of infection, thrombosis and hemorrhage. Aging, lung diseases, splenectomy, corticosteroids and rituximab are risk factors for infection while influenza and pneumococcal vaccines are associated with a 50% decrease of infection risk. Aging, cardiovascular risk factors, lupus anticoagulant and splenectomy are risk factors for thrombosis. The risk of thrombosis associated with corticosteroids and TPO-RAs must be further investigated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Púrpura Trombocitopénica Idiopática / Farmacoepidemiología Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: Fr Revista: Rev Med Interne Año: 2017 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Púrpura Trombocitopénica Idiopática / Farmacoepidemiología Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: Fr Revista: Rev Med Interne Año: 2017 Tipo del documento: Article Pais de publicación: Francia