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Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis.
Frame, J M; Lim, S-E; North, T E.
Afiliación
  • Frame JM; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
  • Lim SE; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
  • North TE; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Harvard Stem Cell Institute, Cambridge, MA, United States.
Methods Cell Biol ; 138: 165-192, 2017.
Article en En | MEDLINE | ID: mdl-28129843
Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic hierarchy, giving rise to each of the blood lineages found throughout the lifetime of the organism. Since the genetic programs regulating HSC development are highly conserved between vertebrate species, experimental studies in zebrafish have not only complemented observations reported in mammals but have also yielded important discoveries that continue to influence our understanding of HSC biology and homeostasis. Here, we summarize findings that have established zebrafish as an important conserved model for the study of hematopoiesis, and describe methods that can be utilized for future investigations of zebrafish HSC biology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Células Madre Hematopoyéticas / Desarrollo Embrionario / Hematopoyesis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Methods Cell Biol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Células Madre Hematopoyéticas / Desarrollo Embrionario / Hematopoyesis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Methods Cell Biol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos