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Formulation of Saudi Propolis into Biodegradable Chitosan Chips for Vital Pulpotomy.
Balata, Gihan F; Abdelhady, Mohamed I S; Mahmoud, Ghada M; Matar, Moustafa A; Abd El-Latif, Amani N.
Afiliación
  • Balata GF; Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah. Saudi Arabia.
  • Abdelhady MIS; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah. Saudi Arabia.
  • Mahmoud GM; Department of Pediatric Dentistry, Faculty of Dentistry, Pharos University, Alexandria. Egypt.
  • Matar MA; Department of Pediatric Dentistry, Faculty of Dentistry, Pharos University, Alexandria. Egypt.
  • Abd El-Latif AN; Department of Oral Pathology, Faculty of Dentistry, Pharos University, Alexandria. Egypt.
Curr Drug Deliv ; 15(1): 97-109, 2018.
Article en En | MEDLINE | ID: mdl-28124615
BACKGROUND: Propolis has been widely used to treat oral cavity disorders, such as endodontal and periodontal diseases and microbial infections. OBJECTIVE: The study aimed at the formulation of commercial Saudi propolis into biodegradable chitosan chips and evaluation of its effectiveness as a pulpotomy agent. METHODS: The standardization of 80% ethanolic propolis extract was performed regarding its total phenolic content, total flavonoid content, quantitative estimation of main polyphenolic constituents and antioxidant activity. Chitosan chips containing propolis extract were prepared by the solvent/ casting method. The investigated variables were % of chitosan polymer (2, 2.5 and 3%), % of plasticizer (1, 5 and 10%) and incorporation of different concentrations of hydroxypropyl methylcellulose (5, 10 and 20% of polymer weight). The chips were characterized for weight and thickness uniformity, content uniformity, pH, percentage moisture loss, swelling index, tensile strength and in vitro propolis release. The optimal propolis chip formulation was further investigated in dogs regarding the short term response of primary dental pulp to propolis chips compared with the most commonly used formocresol preparation. RESULTS: The prepared films were flexible and demonstrated satisfactory physicochemical characteristics. The optimal formulation showed an initial release of about 41.7% of the loaded propolis followed by a sustained release extended up to 7 days. The kinetics study demonstrated that propolis release was controlled by Fick´s diffusion. The optimal propolis chip formulation resulted in less pulpal inflammation compared to formocresol, and produced hard tissue formation in all specimens. CONCLUSION: Formulation of commercial Saudi propolis as a biodegradable chitosan chip is an effective alternative to the commercially available chemical agents for the treatment of vital pulpotomy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Própolis / Pulpotomía / Quitosano Límite: Animals Idioma: En Revista: Curr Drug Deliv Asunto de la revista: FARMACIA / FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2018 Tipo del documento: Article Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Própolis / Pulpotomía / Quitosano Límite: Animals Idioma: En Revista: Curr Drug Deliv Asunto de la revista: FARMACIA / FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2018 Tipo del documento: Article Pais de publicación: Emiratos Árabes Unidos