A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity.
Angew Chem Int Ed Engl
; 56(10): 2619-2622, 2017 03 01.
Article
en En
| MEDLINE
| ID: mdl-28120377
Angiogenin (ANG) is a human ribonuclease that is compromised in patients with amyotrophic lateral sclerosis (ALS). ANG also promotes neovascularization, and can induce hemorrhage and encourage tumor growth. The causal neurodegeneration of ALS is associated with reactive oxygen species, which are also known to elicit the oxidative cleavage of carbon-boron bonds. We have developed a synthetic boronic acid mask that restrains the ribonucleolytic activity of ANG. The masked ANG does not stimulate endothelial cell proliferation but protects astrocytes from oxidative stress. By differentiating between the two dichotomous biological activities of ANG, this strategy could provide a viable pharmacological approach for the treatment of ALS.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ribonucleasa Pancreática
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Ácidos Borónicos
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Especies Reactivas de Oxígeno
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Fármacos Neuroprotectores
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Esclerosis Amiotrófica Lateral
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Neovascularización Patológica
Límite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Alemania