[Genetic analysis and simulation of the virulence of Yersinia pestis]. / Geneticheskii analiz i modelirovanie virulentnosti Yersinia pestis.
Mol Gen Mikrobiol Virusol
; (8): 42-7, 1989 Aug.
Article
en Ru
| MEDLINE
| ID: mdl-2811911
The genetic analysis of Y. pestis virulence factors accomplished in the 358 strain isogenic system allowed us to determine a minimal set of known factors providing pathogenicity. The combination of chromosomal marker Pgm+ and calcium dependence plasmid (pCad) is shown to be sufficient for preserving the virulence of Y. pestis. Experimental modelling of virulence in this microorganism by the genetic exchange methods was carried out. The reduced virulence of the strains Pgm+ and pCad+ for guinea pigs was detected.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Yersinia pestis
/
Genes Bacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Ru
Revista:
Mol Gen Mikrobiol Virusol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
/
VIROLOGIA
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Rusia