ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aß Secretion.

Huang, Yu-Wen Alvin; Zhou, Bo; Wernig, Marius; Südhof, Thomas C

Huang, Yu-Wen Alvin; Zhou, Bo; Wernig, Marius; Südhof, Thomas C.

Afiliación

Huang YA; Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA.
Zhou B; Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University Medical School, Stanford, CA 94305, USA.
Wernig M; Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University Medical School, Stanford, CA 94305, USA.
Südhof TC; Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA. Electronic address: tcs1@stanford.edu.

Cell ; 168(3): 427-441.e21, 2017 01 26.

Article en En | MEDLINE | ID: mdl-28111074

Asunto(s)

Precursor de Proteína beta-Amiloide/genética; Apolipoproteínas E/metabolismo; Sistema de Señalización de MAP Quinasas; Enfermedad de Alzheimer/metabolismo; Animales; Células Madre Embrionarias/citología; Células Madre Embrionarias/metabolismo; Fibroblastos/metabolismo; Humanos; Ratones; Neuronas/metabolismo; Isoformas de Proteínas/metabolismo

Palabras clave

APP; Alzheimer's disease; ApoE; Aß; CRISPR; CRISPRi; DLK; MAP kinase signaling; amyloid precursor protein; apolipoprotein E; beta amyloid; cFos; dual leucine-zipper kinase; transcription

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas E / Precursor de Proteína beta-Amiloide / Sistema de Señalización de MAP Quinasas Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Cell Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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