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Galectin-1 expression is associated with tumour immunity and prognosis in gingival squamous cell carcinoma.
Noda, Yuri; Kishino, Mitsunobu; Sato, Sunao; Hirose, Katsutoshi; Sakai, Manabu; Fukuda, Yasuo; Murakami, Shumei; Toyosawa, Satoru.
Afiliación
  • Noda Y; Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Japan.
  • Kishino M; Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Japan.
  • Sato S; Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Japan.
  • Hirose K; Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Japan.
  • Sakai M; Clinical Laboratory, Osaka University Dental Hospital, Suita, Japan.
  • Fukuda Y; Clinical Laboratory, Osaka University Dental Hospital, Suita, Japan.
  • Murakami S; Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, Suita, Japan.
  • Toyosawa S; Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Japan.
J Clin Pathol ; 70(2): 126-133, 2017 Feb.
Article en En | MEDLINE | ID: mdl-28108653
AIMS: Galectin-1 (Gal-1) is a ß-galactoside-binding protein that overexpresses in cancer and plays pivotal roles in tumour progression. Gal-1 regulates angiogenesis and invasiveness, and suppresses tumour immunity by inducing T cell apoptosis. Several studies have examined the relationship between Gal-1 and tumour immunosuppression in vivo, but they have not examined the clinicopathological relationship between Gal-1 expression and apoptotic T cell number in human tissue. In this study, we investigated the association between Gal-1 expression and apoptotic T cells of gingival squamous cell carcinoma (GSCC), as well as other clinicopathological factors. METHODS: Immunohistochemical investigation of 80 GSCC specimens using anti-Gal-1, anti-CD3, anti-CD4, anti-CD8, anti-CD34, antipodoplanin and anticleaved caspase-3 (CC-3) antibodies was performed. Relative expression levels of CD3 and CC-3, as well as CD8 and CC-3 were assessed simultaneously by double immunostaining. Gal-1 expression and T cell apoptosis were evaluated in 6 high-power fields (3 in the tumour and 3 in the stroma). RESULTS: Gal-1 expression in GSCC was significantly correlated with T cell infiltration (p=0.036), and apoptosis of CD3+ and CD8+ T cells (p<0.001). Moreover, Gal-1 expression was significantly correlated with lymph node metastasis (p=0.021), histological differentiation (p<0.001) and overall survival rate (p=0.021). CONCLUSIONS: These findings suggest that Gal-1 plays an important role in immune escape of GSCC cells, and Gal-1 expression level may be a useful clinicopathological prognostic marker for GSCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gingivales / Carcinoma de Células Escamosas / Escape del Tumor / Galectina 1 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: J Clin Pathol Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gingivales / Carcinoma de Células Escamosas / Escape del Tumor / Galectina 1 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: J Clin Pathol Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido