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Comparative Effectiveness of Busulfan and Fludarabine versus Fludarabine and 400 cGy Total Body Irradiation Conditioning Regimens for Acute Myeloid Leukemia/Myelodysplastic Syndrome.
Mustafa Ali, Moaath; Abounader, Donna M; Rybicki, Lisa A; Yurch, Melissa A; Starn, Jamie; Ferraro, Christina; Winslow, Victoria; Hamilton, Betty K; Gerds, Aaron T; Liu, Hien; Dean, Robert; Hill, Brian T; Pohlman, Brad; Andresen, Steven; Hanna, Rabi; Kalaycio, Matt; Bolwell, Brian J; Majhail, Navneet S; Sobecks, Ronald M.
Afiliación
  • Mustafa Ali M; Internal Medicine, Cleveland Clinic, Cleveland, Ohio.
  • Abounader DM; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Rybicki LA; Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio.
  • Yurch MA; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Starn J; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Ferraro C; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Winslow V; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Hamilton BK; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Gerds AT; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Liu H; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Dean R; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Hill BT; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Pohlman B; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Andresen S; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Hanna R; Pediatric Hematology/Oncology, Cleveland Clinic, Cleveland, Ohio.
  • Kalaycio M; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Bolwell BJ; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Majhail NS; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
  • Sobecks RM; Blood and Marrow Transplant Program, Cleveland Clinic Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address: sobeckr@ccf.org.
Biol Blood Marrow Transplant ; 23(5): 776-781, 2017 May.
Article en En | MEDLINE | ID: mdl-28108271
Allogeneic hematopoietic cell transplantation conditioning regimen intensity has varied for patients with acute myeloid leukemia and myelodysplastic syndrome. A comparative effectiveness analysis was performed to assess outcomes of busulfan and fludarabine (BuFlu) versus those of fludarabine and 400 cGy total body irradiation (FluTBI) conditioning. Thirty-three subjects received BuFlu and 38 received FluTBI. The BuFlu group received more red blood cell transfusions (P = .02) and had a longer time to platelet recovery (P = .004). There were no differences between the regimens regarding incidence of acute or chronic graft-versus-host disease (GVHD), quality of life, or 2-year outcome estimates for relapse (48; 95% confidence interval [CI], 30 to 64 and 50; 95% CI, 33 to 65), nonrelapse mortality (29; 95% CI, 14 to 45 and 29; 95% CI, 15 to 44), relapse-free survival (27; 95% CI, 13 to 43 and 29; 95% CI, 16 to 44), and overall survival (35; 95% CI, 19 to 51; and 37; 95% CI, 22 to 52), respectively. These comparable outcomes have implications for health care resource utilization. Future prospective investigation comparing these regimens with larger patient cohorts and additional strategies to prevent relapse and limit toxicities as well as cost-effectiveness analyses are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Acondicionamiento Pretrasplante Tipo de estudio: Etiology_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biol Blood Marrow Transplant Asunto de la revista: HEMATOLOGIA / TRANSPLANTE Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Acondicionamiento Pretrasplante Tipo de estudio: Etiology_studies Aspecto: Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biol Blood Marrow Transplant Asunto de la revista: HEMATOLOGIA / TRANSPLANTE Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos