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Essential oil composition and antinociceptive activity of Thymus capitatus.
Gonçalves, Juan Carlos Ramos; de Meneses, Danilo Andrade; de Vasconcelos, Aliny Pereira; Piauilino, Celyane Alves; Almeida, Fernanda Regina de Castro; Napoli, Edoardo Marco; Ruberto, Giuseppe; de Araújo, Demetrius Antônio Machado.
Afiliación
  • Gonçalves JC; a Núcleo de Pesquisas em Plantas Medicinais, Universidade Federal do Piauí , Teresina , Brazil.
  • de Meneses DA; b Centro de Biotecnologia, Universidade Federal da Paraíba , João Pessoa , Brazil.
  • de Vasconcelos AP; b Centro de Biotecnologia, Universidade Federal da Paraíba , João Pessoa , Brazil.
  • Piauilino CA; b Centro de Biotecnologia, Universidade Federal da Paraíba , João Pessoa , Brazil.
  • Almeida FR; a Núcleo de Pesquisas em Plantas Medicinais, Universidade Federal do Piauí , Teresina , Brazil.
  • Napoli EM; a Núcleo de Pesquisas em Plantas Medicinais, Universidade Federal do Piauí , Teresina , Brazil.
  • Ruberto G; c Consiglio Nazionale delle Ricerche, Istituto di Chimica Biomolecolare , Catania , Italy.
  • de Araújo DA; c Consiglio Nazionale delle Ricerche, Istituto di Chimica Biomolecolare , Catania , Italy.
Pharm Biol ; 55(1): 782-786, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28103733
CONTEXT: The essential oil (EO) from Thymus capitatus Hoff. et Link. (Lamiaceae) has been traditionally used for its medicinal properties, such as anti-inflammatory, analgesic, antioxidant and antimicrobial properties. OBJECTIVE: Characterize the constituents from T. capitatus EO and further evaluate the antinociceptive activity by in vivo and in vitro procedures. MATERIALS AND METHODS: Gas chromatography-mass spectrometry was used to identify and quantify the constituents of the T. capitatus EO. The antinociceptive activity was evaluated in vivo by the glutamate-induced nociception model in male Swiss mice (25 g), at doses of 3, 6 and 12 mg/kg, 1 h before evaluation of the licking time response (0-15 min). The mechanism of T. capitatus EO (1-500 µg/mL) on the isolated nerve excitability of Wistar rat (300 g) was assessed by the single sucrose technique. RESULTS AND DISCUSSION: The EO of T. capitatus presented 33 components, mainly monoterpenes and sesquiterpenes, carvacrol (ca. 80%) was its major constituent. T. capitatus EO induced antinociception in orally treated mice (3, 6, and 12 mg/kg) reducing the licking time from control (100.3 ± 11.9 s) to 84.8 ± 12.2, 62.7.6 ± 9.9, and 41.5 ± 12.7 s, respectively (n = 8; p < 0.05). Additionally, we have demonstrated that T. capitatus EO (500 µg/mL) decreased the compound action potential amplitude (VCAP) of about 80.0 ± 4.3% from control recordings (n = 4; p < 0.05). Such activity was presumably mediated through a voltage-gated Na+ channels. CONCLUSIONS: The present study demonstrated the antinociceptive activity of Thymus capitatus essential oil, which acts via peripheral nervous excitability blockade.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites de Plantas / Aceites Volátiles / Thymus (Planta) / Analgésicos Límite: Animals Idioma: En Revista: Pharm Biol Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites de Plantas / Aceites Volátiles / Thymus (Planta) / Analgésicos Límite: Animals Idioma: En Revista: Pharm Biol Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido