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Predicting biochemical recurrence in patients with high-risk prostate cancer using the apparent diffusion coefficient of magnetic resonance imaging.
Yoon, Min Young; Park, Juhyun; Cho, Jeong Yeon; Jeong, Chang Wook; Ku, Ja Hyeon; Kim, Hyeon Hoe; Kwak, Cheol.
Afiliación
  • Yoon MY; Department of Urology, Seoul National University Hospital, Seoul, Korea.
  • Park J; Department of Urology, Seoul National University Hospital, Seoul, Korea.
  • Cho JY; Department of Radiology, Seoul National University Hospital, Seoul, Korea.
  • Jeong CW; Department of Urology, Seoul National University Hospital, Seoul, Korea.
  • Ku JH; Department of Urology, Seoul National University Hospital, Seoul, Korea.
  • Kim HH; Department of Urology, Seoul National University Hospital, Seoul, Korea.
  • Kwak C; Department of Urology, Seoul National University Hospital, Seoul, Korea.
Investig Clin Urol ; 58(1): 12-19, 2017 01.
Article en En | MEDLINE | ID: mdl-28097263
PURPOSE: We aimed to investigate whether the apparent diffusion coefficient (ADC) value in diffusion-weighted magnetic resonance imaging predicts the prognoses of patients with high-risk prostate cancer. MATERIALS AND METHODS: A total of 157 patients with high-risk prostate cancer (based on D'Amico's criteria) were included in the analysis. Patients underwent preoperative 3.0 Tesla magnetic resonance imaging within 2 months before radical prostatectomy. Those who received neoadjuvant hormone therapy (33 persons) or radiation therapy (18 persons) were excluded. The ADC of the tumor calculated from 2 b-values (0 and 1,000 s/mm2) was measured. Areas under receiver operating characteristics curves were calculated to maximize the accuracy of the ADC value. Based on the obtained cutoff value, the patients were stratified into 2 groups: Group A consisted of patients with ADC values <746×10-6 mm2/s and group B comprised those with ADC values ≥746×10-6 mm2/s. RESULTS: Group A showed higher rate of lymph positive and biochemical recurrence (BCR) rates than group B. Kaplan-Meier analysis showed that the BCR-free survival rate of group A was much lower than that of group B (p<0.001). On Cox proportional regression analyses, ADC group A (hazard ratio [HR], 3.238, p=0.002) and pathologic lymph node positive (HR, 2.242; p=0.009) were independent predictors of BCR. CONCLUSIONS: In patients with high-risk prostate cancer, ADC value is significantly associated with BCR-free survival. Therefore, the ADC value is a useful tool for predicting the prognoses of these high-risk patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Antígeno Prostático Específico / Imagen de Difusión por Resonancia Magnética / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Investig Clin Urol Año: 2017 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Antígeno Prostático Específico / Imagen de Difusión por Resonancia Magnética / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Investig Clin Urol Año: 2017 Tipo del documento: Article Pais de publicación: Corea del Sur