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Pathogen-mediated manipulation of arthropod microbiota to promote infection.
Abraham, Nabil M; Liu, Lei; Jutras, Brandon Lyon; Yadav, Akhilesh K; Narasimhan, Sukanya; Gopalakrishnan, Vissagan; Ansari, Juliana M; Jefferson, Kimberly K; Cava, Felipe; Jacobs-Wagner, Christine; Fikrig, Erol.
Afiliación
  • Abraham NM; Section of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
  • Liu L; Howard Hughes Medical Institute, Chevy Chase, MD 20815.
  • Jutras BL; Section of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; lei.liu.ll69@yale.edu erol.fikrig@yale.edu.
  • Yadav AK; Howard Hughes Medical Institute, Chevy Chase, MD 20815.
  • Narasimhan S; Microbial Sciences Institute, Yale University, West Haven, CT 06516.
  • Gopalakrishnan V; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520.
  • Ansari JM; Laboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå Center for Microbial Research, Umeå University, 901 87 Umea, Sweden.
  • Jefferson KK; Section of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
  • Cava F; Section of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
  • Jacobs-Wagner C; Howard Hughes Medical Institute, Chevy Chase, MD 20815.
  • Fikrig E; Rush Medical College, Rush University Medical Center, Chicago, IL 60612.
Proc Natl Acad Sci U S A ; 114(5): E781-E790, 2017 01 31.
Article en En | MEDLINE | ID: mdl-28096373
Arthropods transmit diverse infectious agents; however, the ways microbes influence their vector to enhance colonization are poorly understood. Ixodes scapularis ticks harbor numerous human pathogens, including Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis. We now demonstrate that A. phagocytophilum modifies the I. scapularis microbiota to more efficiently infect the tick. A. phagocytophilum induces ticks to express Ixodes scapularis antifreeze glycoprotein (iafgp), which encodes a protein with several properties, including the ability to alter bacterial biofilm formation. IAFGP thereby perturbs the tick gut microbiota, which influences the integrity of the peritrophic matrix and gut barrier-critical obstacles for Anaplasma colonization. Mechanistically, IAFGP binds the terminal d-alanine residue of the pentapeptide chain of bacterial peptidoglycan, resulting in altered permeability and the capacity of bacteria to form biofilms. These data elucidate the molecular mechanisms by which a human pathogen appropriates an arthropod antibacterial protein to alter the gut microbiota and more effectively colonize the vector.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ixodes / Anaplasma phagocytophilum / Interacciones Huésped-Patógeno / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ixodes / Anaplasma phagocytophilum / Interacciones Huésped-Patógeno / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos