Preformulation Characterization, Stabilization, and Formulation Design for the Acrylodan-Labeled Glucose-Binding Protein SM4-AC.

Sahni, Neha; Chaudhuri, Rajoshi; Hickey, John M; Manikwar, Prakash; D'Souza, Ajit; Metters, Andrew; Joshi, Sangeeta B; Middaugh, C Russell; Volkin, David B

Sahni, Neha; Chaudhuri, Rajoshi; Hickey, John M; Manikwar, Prakash; D'Souza, Ajit; Metters, Andrew; Joshi, Sangeeta B; Middaugh, C Russell; Volkin, David B.

Afiliación

Sahni N; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047.
Chaudhuri R; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047.
Hickey JM; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047.
Manikwar P; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047.
D'Souza A; BD Medical-Diabetes Care, Andover, Massachusetts 01810.
Metters A; BD Medical-Diabetes Care, Andover, Massachusetts 01810.
Joshi SB; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047.
Middaugh CR; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047.
Volkin DB; Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas 66047. Electronic address: volkin@ku.edu.

J Pharm Sci ; 106(5): 1197-1210, 2017 05.

Article en En | MEDLINE | ID: mdl-28088457

Asunto(s)

2-Naftilamina/análogos & derivados; Química Farmacéutica/métodos; Composición de Medicamentos/métodos; Diseño de Fármacos; Glucosa/química; Glucosa/metabolismo; 2-Naftilamina/química; 2-Naftilamina/metabolismo; Dicroismo Circular/métodos; Estabilidad de Medicamentos; Unión Proteica/fisiología

Palabras clave

acrylodan fluorescence; excipients; glucose binding; high-throughput fluorescence assay; physicochemical characterization; preformulation; stabilization

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Química Farmacéutica / Composición de Medicamentos / Glucosa / 2-Naftilamina Idioma: En Revista: J Pharm Sci Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos

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