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Effect of childhood general traumas on suicide attempt depends on TPH2 and ADARB1 variants in psychiatric patients.
Karanovic, Jelena; Ivkovic, Maja; Jovanovic, Vladimir M; Svikovic, Sasa; Pantovic-Stefanovic, Maja; Brkusanin, Milos; Damjanovic, Aleksandar; Brajuskovic, Goran; Savic-Pavicevic, Dusanka.
Afiliación
  • Karanovic J; Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO box 43, Belgrade, 11000, Serbia.
  • Ivkovic M; Clinic for Psychiatry, Clinical Centre of Serbia, Pasterova 2, Belgrade, 11000, Serbia.
  • Jovanovic VM; Medical School, University of Belgrade, Doktora Subotica 8, Belgrade, 11000, Serbia.
  • Svikovic S; Department of Genetic Research, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Bulevar despota Stefana 142, Belgrade, 11000, Serbia.
  • Pantovic-Stefanovic M; Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO box 43, Belgrade, 11000, Serbia.
  • Brkusanin M; Clinic for Psychiatry, Clinical Centre of Serbia, Pasterova 2, Belgrade, 11000, Serbia.
  • Damjanovic A; Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO box 43, Belgrade, 11000, Serbia.
  • Brajuskovic G; Clinic for Psychiatry, Clinical Centre of Serbia, Pasterova 2, Belgrade, 11000, Serbia.
  • Savic-Pavicevic D; Medical School, University of Belgrade, Doktora Subotica 8, Belgrade, 11000, Serbia.
J Neural Transm (Vienna) ; 124(5): 621-629, 2017 05.
Article en En | MEDLINE | ID: mdl-28084537
Suicidal behavior has been associated with a deficient serotonin neurotransmission which is likely a consequence of individual genetic architecture, exposure to environmental factors and interactions of those factors. We examined whether the interaction of child abuse, TPH2 (tryptophan hydroxylase 2) variant rs4290270, affecting alternative splicing and editing of TPH2 pre-mRNAs, and ADARB1 (adenosine deaminase acting on RNA B1) variants rs4819035 and rs9983925 may influence the risk for suicide attempt in psychiatric patients. TPH2 rs4290270 was genotyped in 165 suicide attempters and 188 suicide non-attempters diagnosed with major depressive disorder, bipolar disorder and schizophrenia. Genotyping data for ADARB1 variants were taken over from our previous study. Child abuse before the age of 18 years was assessed using the Early Trauma Inventory-Self Report. Generalized linear models and backward selection were applied to identify the main and interacting effects of environmental and genetic factors, including psychiatric diagnoses, patients' gender and age as covariates. Childhood general traumas were independently associated with suicide attempt. Two-way interaction between TPH2 rs4290270 and general traumas revealed that TT homozygotes with a history of general traumas had an increased risk for suicide attempt. Three-way interaction of general traumas, TPH2 rs4290270 and ADARB1 rs4819035 indicated that the highest predisposition to suicide attempt was observed in individuals who experienced general traumas and were TT homozygote for rs4290270 and TT homozygote for rs4819035. Our findings suggest that the risk for suicide attempt in psychiatric patients exposed to an adverse childhood environment may depend on TPH2 and ADARB1 variants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intento de Suicidio / Triptófano Hidroxilasa / Adenosina Desaminasa / Proteínas de Unión al ARN / Adultos Sobrevivientes del Maltrato a los Niños / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Neural Transm (Vienna) Año: 2017 Tipo del documento: Article Pais de publicación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intento de Suicidio / Triptófano Hidroxilasa / Adenosina Desaminasa / Proteínas de Unión al ARN / Adultos Sobrevivientes del Maltrato a los Niños / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Neural Transm (Vienna) Año: 2017 Tipo del documento: Article Pais de publicación: Austria